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一般說明
Anti-C-KIT Antibody detects endogenous levels of total C-KIT protein.
KIT (proto-oncogene) is a type III receptor tyrosine kinase (RTK). It codes for a tyrosine kinase receptor (CD117). It is located on human chromosome 4q12.
The KIT (proto-oncogene receptor tyrosine kinase) gene is mapped to human chromosome 4q12. It encodes for a transmembrane glycoprotein that belongs to the receptor tyrosine kinases subclass III family.
免疫原
The antiserum was produced against synthesized peptide derived from human c-Kit.
Immunogen Range: 688-737
Immunogen Range: 688-737
生化／生理作用
KIT (proto-oncogene receptor tyrosine kinase) is considered to be an important hematopoietic growth factor receptor. It is known to exhibit tyrosine kinase activity that is associated with a variety of biologic processes, such as cell proliferation, survival, apoptosis, and motility. Downregulation of this gene is observed during the disease progression of multiple myeloma. Variation in the gene contributes to at least 2% of all melanomas and is most frequently observed in acral and mucosal melanomas. Mutations in KIT is associated with gastrointestinal stromal tumors.
KIT (proto-oncogene) participates in cell signal transduction. It also participates in the progression of hematopoietic stem cells, melanocytes, germ cells, mast cells and interstitial cells of Cajal. Mutations in KIT gene results in gastrointestinal stromal tumors.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
KIT Exon 11 Codons 557?558 Deletion Mutation Promotes Liver Metastasis Through the CXCL12/CXCR4 Axis in Gastrointestinal Stromal Tumors
Wang HC, et al.
Clinical Cancer Research, 22(14), 3477-3487 (2016)
Efficacy and safety of nilotinib in patients with KIT-mutated metastatic or inoperable melanoma: final results from the global, single-arm, phase II TEAM trial
Guo J, et al.
Annals of Oncology, 28(6), 1380-1387 (2017)
Loss of c-KIT expression in thyroid cancer cells.
Franceschi S, et al.
PLoS ONE, 12(3) (2017)
The Assessment of CD56 and CD117 Expressions at the Time of the Diagnosis in Multiple Myeloma Patients
Ceran F, et al.
Turkish journal of haematology : official journal of Turkish Society of Haematology, 34(3), 226-226 (2017)
KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors
Lux ML, et al.
The American Journal of Pathology, 156(3), 791-795 (2000)
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