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Merck
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主要文件

SAB4501467

Sigma-Aldrich

Anti-APLP2 antibody produced in rabbit

affinity isolated antibody

别名:

APLP2, APP2, APPH, Amyloid protein homolog, Amyloid-like protein 2 precursor

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 86 kDa

物種活性

rat, human, mouse

濃度

~1 mg/mL

技術

ELISA: 1:40000
western blot: 1:500-1:1000

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... APLP2(334)

一般說明

Anti-APLP2 Antibody detects endogenous levels of total APLP2 protein.
APLP2 (amyloid precursor-like protein 2) belongs to the amyloid precursor protein family. It is mapped to human chromosome 11q24.

免疫原

The antiserum was produced against synthesized peptide derived from human APLP2.

Immunogen Range: 241-290

生化/生理作用

Amyloid precursor-like protein 2 (APLP2) aids in the proliferation of pancreatic cancer growth and metastasis. It controls the expression of cell surface proteins. APLP2 plays an important role in chromosome replication and segregation.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Mechanism for amyloid precursor-like protein 2 enhancement of major histocompatibility complex class I molecule degradation.
Tuli A, et al.
The Journal of Biological Chemistry, 284(49), 34296-34307 (2009)
Identification and expression of the first nonmammalian amyloid-beta precursor-like protein APLP2 in the amphibian Xenopus laevis.
Collin RW, et al.
European Journal of Biochemistry, 271(10), 1906-1912 (2004)
Poomy Pandey et al.
Oncotarget, 6(4), 2064-2075 (2015-01-13)
Amyloid precursor-like protein 2 (APLP2) is aberrantly expressed in pancreatic cancer. Here we showed that APLP2 is increased in pancreatic cancer metastases, particularly in metastatic lesions found in the diaphragm and intestine. Examination of matched human primary tumor-liver metastasis pairs

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