SAB4501323

Anti-GRM5 antibody produced in rabbit

affinity isolated antibody

• 别名: GPRC1E, GRM5, MGLUR5, Metabotropic glutamate receptor 5, mGluR5
• 分類程式碼代碼: 12352203
• NACRES: NA.41

属性

• 生物源: rabbit
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen 132 kDa
• 物種活性: mouse, rat, human
• 濃度: ~1 mg/mL
• 技術: ELISA: 1:10000; immunofluorescence: 1:100-1:500; western blot: 1:500-1:1000
• NCBI登錄號: P41594
• UniProt登錄號: P41594
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... GRM5(2915)

说明

一般說明

Glutamate metabotropic receptor 5 (GRM5)/metabotropic glutamate receptor subtype 5 (mGluR5) is a seven-transmembrane G-protein-coupled protein. It contains two binding sites and a structural connection to the N-methyl-D-aspartate receptor (NMDA) through a scaffold protein chain. GRM5 gene is located on human chromosome 11q14.2. Anti-GRM5 antibody detects endogenous levels of total GRM5 protein.

免疫原

The antiserum was produced against synthesized peptide derived from human GRM5.

Immunogen Range: 21-70

生化／生理作用

Glutamate metabotropic receptor 5 (GRM5) protein participates in glutamate signaling, supporting the action of natural stimuli, the excitability of N-methyl-D-aspartate receptor (NMDA) receptor, and abnormal synaptic plasticity in addiction. It is important for the pathophysiology and to treat eating disorders. It controls the developmental variation dependent on glutamate. It also plays a key role in adaptive synaptic plasticity, long-term potentiation, and learning. The pharmacological inhibitors of mGlu5 may have a therapeutic possibility in Bulimia nervosa (BN). Absence of mGluR5 plays a pathogenic role in autism spectrum disorder (ASD).

特點和優勢

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外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: nwg
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable