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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 129 kDa
物種活性
human
濃度
~1 mg/mL
技術
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... COL1A2(1278)
一般說明
Anti-Collagen I α2 Antibody detects endogenous levels of total Collagen I α2 protein.
Collagen I α2 (COL1A2) is located on human chromosome 7q22.1. Human COL1A2 gene consists of two dinucleotide repeats: one in the 5′-flanking region of the gene, made of of poly(dC–dA) and poly(dC–dG) and the other in the first intron comprised of poly(dG–dT).
免疫原
The antiserum was produced against synthesized peptide derived from human Collagen I alpha2.
Immunogen Range: 471-520
Immunogen Range: 471-520
應用
Anti-Collagen I α2 antibody has been used to quantify protein expression levels after western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
生化／生理作用
Collagen I α2 (COL1A2) is essential to maintain elasticity of the vessel wall and is an important constituent of the extracellular matrix. Mutations in COL1A2 results in osteogenesis imperfecta (OI).
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Angiotensin II increases fibronectin and collagen I through the ?-catenin-dependent signaling in mouse collecting duct cells.
Cuevas CA, et al.
American Journal of Physiology: Renal Physiology, 308(4), F358-F365 (2014)
Mutation in a gene for type I procollagen (COL1A2) in a woman with postmenopausal osteoporosis: evidence for phenotypic and genotypic overlap with mild osteogenesis imperfecta.
Spotila LD, et al.
Proceedings of the National Academy of Sciences of the USA, 88(12), 5423-5427 (1991)
Transcriptional regulation of the human type I collagen ?2 (COL1A2) gene by the combination of two dinucleotide repeats.
Akai J, et al.
Gene, 239(1), 65-73 (1999)
Collagen type I ?2 (COL1A2) is the susceptible gene for intracranial aneurysms.
Yoneyama T, et al.
Stroke, 35(2), 443-448 (2004)
Influence of COL1A2 gene variants on the incidence of hypertensive intracerebral hemorrhage in a Chinese population.
Tian DZ, et al.
Genetics and molecular research : GMR, 15(1) (2015)
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