推荐产品
生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
TH-2, monoclonal
形狀
buffered aqueous solution
物種活性
rabbit, human, sheep, guinea pig, rat, bovine, mouse
濃度
~1.0 mg/mL
技術
immunoblotting: 0.25-0.5 μg/mL using whole extracts of rat PC-12 cells.
同型
IgG1
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TH(7054)
一般說明
Anti-Tyrosine Hydroxylase antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma TH-2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with purified rat Tyrosine Hydroxylase. Tyrosine Hydroxylase (TH) also known as tyrosine 3- monooxygenase, is encoded by the gene mapped to human chromosome 11p15.5. It is a tetrameric enzyme composed of four subunits. Four TH Isoforms were identified in humans.
免疫原
purified rat Tyrosine Hydroxylase
應用
Anti-Tyrosine Hydroxylase antibody, Mouse monoclonal has been used in various immunochemical techniques including immunoblotting, immunohistochemistry, immunofluorescence and immunoprecipitation.
生化／生理作用
Tyrosine Hydroxylase (TH) catalyzes the hydroxylation of L-tyrosine to L-3,4-dihydroxyphenylalanine (L-dopa) in brain and adrenal medulla which is the initial and rate limiting step of the neurotransmitters and hormones catecholamines (dopamine, norepinephrine and epinephrine) biosynthesis. Therefore, TH plays a key role in the physiology of adrenergic neurons. Tyrosine Hydroxylase (TH) deficiency is associated with the development of wide variety of phenotypic spectrum such as several types of dystonia, early-onset of Parkinson′s, cerebral palsy or spastic paraplegia and both primary and secondary deficiencies of cerebrospinal fluid (CSF) neurotransmitter metabolites.
外觀
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Tyrosine Hydroxylase and Regulation of Dopamine Synthesis
Daubner SC, et al.
Archives of Biochemistry and Biophysics, 508, 1-1 (2011)
Molecular Aspects of Alcohol and Nutrition: A Volume in the Molecular Nutrition Series (2015)
Species differences in the expression of multiple tyrosine hydroxylase protein isoforms
Haycock J W
Journal of Neurochemistry, 81, 947-953 (2002)
H Ichinose et al.
Biochemical and biophysical research communications, 195(1), 158-165 (1993-08-31)
Humans produce four different forms of tyrosine hydroxylase (TH) mRNA via alternative splicing of the gene. Here we demonstrate that New- and Old-World monkeys and the gorilla produce only two of the TH isoforms. Comparison among the genomic DNA sequences
Tyrosine hydroxylase deficiency
GeneReviews(?) (2017)
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