推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~58 kDa
物種活性
human, rat, mouse
濃度
~1.0 mg/mL
技術
indirect immunofluorescence: 2.5-5 μg/mL using human HeLa cells.
western blot: 2.5-5.0 μg/mL using whole extracts of HEK-293T cells over-expressing mouse NMD3.
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... NMD3(51068)
mouse ... Nmd3(97112)
rat ... Nmd3(310512)
一般說明
NMD3 ribosome export adaptor (NMD3) is an adaptor for 60S subunit export via the export receptor CRM1 (XPO1). In human, the C-terminal domain of NMD3 comprises a CRM1- dependent leucine-rich nuclear export signal (NES) and a nuclear localization signal (NLS) in its. Two zinc-binding centres and the ribosome-binding domain forms the N-terminal domain.
免疫原
peptide corresponding to an internal region of human NMD3, conjugated to KLH. The corresponding sequence is identical in mouse, rat, monkey, bovine and dog.
應用
Anti-NMD3 antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
生化／生理作用
NMD3 ribosome export adaptor (NMD3) is a highly conserved nucleocytoplasmic shuttling protein, essential for nuclear export of 60S ribosomal subunits.
外觀
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates
Trotta CR, et al.
The Embo Journal, 22(11), 2841-2851 (2003)
Characterization of the nuclear export adaptor protein Nmd3 in association with the 60S ribosomal subunit
Sengupta J, et al.
The Journal of Cell Biology, 189(7), 1079-1086 (2010)
Baoyan Bai et al.
Nucleus (Austin, Tex.), 4(4), 315-325 (2013-06-21)
CRM1 is an export factor that together with its adaptor NMD3 transports numerous cargo molecules from the nucleus to cytoplasm through the nuclear pore. Previous studies have suggested that CRM1 and NMD3 are detected in the nucleolus. However, their localization
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