推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~90 kDa
物種活性
mouse, rat, human
濃度
~1.0 mg/mL
技術
indirect immunofluorescence: 10-20 μg/mL using rat NRK cells
western blot: 2.5-5.0 μg/mL using whole extracts of human U-2-OS and mouse Neuro-2a cells
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TFRC(7037)
mouse ... Tfrc(22042)
rat ... Tfrc(64678)
一般說明
Transferrin receptor (TFRC), also known as p90, CD71, TFR and TFR1, is a transmembrane glycoprotein. It is composed of two disulphide-bonded sub-units, contains three N-linked glycan units and is post-translationally modified with phosphate and fatty acyl groups.
免疫原
synthetic peptide corresponding to an internal sequence of human TFRC, conjugated to KLH
應用
Anti-TFRC antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
生化／生理作用
Transferrin receptor (TFRC) mediates cellular iron uptake. It binds iron bound transferrin on the cell surface, and the receptor ligand complex undergoes endocytosis via clathrin coated pits. Endosomal acidification leads to iron release, which is transported to the cytosol or to the mitochondria in erythroid cells. The apotransferrin receptor complex is then recycled to the cell surface, where the affinity of apotransferrin for TFRC drops, resulting in its dissociation. TFRC is necessary for development of erythrocytes and the nervous system.
外觀
solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Regulation of cellular iron metabolism
Wang J and Pantopoulos K
The Biochemical Journal, 434(3), 365-381 (2011)
Transferrin receptor gene and protein expression and localization in human IUGR and normal term placentas
Mando C, et al.
Placenta, 32(1), 44-50 (2011)
1.6 Mb deletion in chromosome band 3q29 associated with eye abnormalities
Tyshchenko N, et al.
European Journal of Medical Genetics, 52(2-3), 128-130 (2009)
Divya Teja Dondapati et al.
Membranes, 11(12) (2021-12-24)
The cellular prion protein (PrPC) is renowned for its infectious conformational isoform PrPSc, capable of templating subsequent conversions of healthy PrPCs and thus triggering the group of incurable diseases known as transmissible spongiform encephalopathies. Besides this mechanism not being fully
Peina Wang et al.
Cell death & disease, 12(5), 447-447 (2021-05-07)
Ischaemic stroke is becoming the most common cerebral disease in aging populations, but the underlying molecular mechanism of the disease has not yet been fully elucidated. Increasing evidence has indicated that an excess of iron contributes to brain damage in
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