SAB4200321
Anti-PTPRF (C-terminal) antibody produced in rabbit
IgG fraction of antiserum
别名:
Anti-LAR, Anti-Leukocyte antigen-related tyrosine phosphatase, Anti-Leukocyte common antigen-related tyrosine phosphatase, Anti-Tyrosine protein phosphatase receptor type F
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所有图片(2)
About This Item
分類程式碼代碼:
12352203
NACRES:
NA.44
推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~150 kDa
antigen ~210 kDa
antigen ~85 kDa
物種活性
human
技術
immunoprecipitation (IP): 5-10 μL using lysates of HEK-293T cells over-expressing human PTPRF.
western blot: 1:500-1:1000 using lysates of HEK-293T cells over-expressing human PTPRF.
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... PTPRF(5792)
mouse ... Ptprf(19268)
rat ... Ptprf(360406)
一般說明
PTPRF or leukocyte common antigen-related protein (LAR) is a widely expressed protein tyrosine phosphatase with an extracellular receptor region that resembles a cell adhesion molecule.
Protein tyrosine phosphatase, receptor type F (PTPRF) consists of noncovalently bound subunits designated as E (extracellular) and P (phosphatase) subunits that are derived from a precursor protein by proteolytic processing. The E subunit (150 kDa) has three immunoglobulin-like domains and eight fibronectin III-like domains, and the P subunit (85 kDa) has a short extracellular domain, a transmembrane segment and tandem cytoplasmic PTP catalytic domains.
特異性
The antibody recognizes both the extracellular and the cytoplasmic subunits of human PTPRF. Anti-PTPRF (C-terminal) antibody is specific for the P- subunit and the whole PTPRF protein from Human origin. Detection of the PTPRF bands by immunoblotting is specifically inhibited by the immunizing peptide.
應用
Anti-PTPRF (C-terminal) antibody produced in rabbit has been used in an enzyme based assay of protein tyrosine phosphatase 1 (PTP1).
The antibody may be used in several immunochemical techniques including immunoblotting (∼210, ∼150, and ∼85 kDa) and immunoprecipitation.
生化／生理作用
Protein tyrosine phosphatase, receptor type F (PTPRF) removes phosphate group from β-catenin, an event that may subsequently facilitate cell-cell adhesion and ensure the stability of the cadherin complex. This phosphatase has also been implicated in various cellular processes such as neurite growth, nerve regeneration, actin remodeling and regulation of insulin function. Insulin receptor, epidermal growth factor receptor (EGF) receptor, hepatocyte growth factor (HGF) receptor and rearranged during transfection (RET) have been reported as substrates of PTPRF.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
2, 5-DISUBSTITUTED OXADIAZOLE AND IT?S DERIVATIVE
INHIBIT PROTEIN TYROSINE PHOSPHATASE PTP1B, ENHANCING
INSULIN RECEPTOR PHOSPHORYLATION
Athare CL, et al.
World Journal of Pharmaceutical Research, 3(2), 2232-2247 (2014)
Differential effects of leukocyte common antigen-related protein on biochemical and biological activities of RET-MEN2A and RET-MEN2B mutant proteins
Qiao S, et al.
The Journal of Biological Chemistry, 276(12), 9460-9467 (2001)
M Streuli et al.
The EMBO journal, 11(3), 897-907 (1992-03-01)
The human transmembrane molecule LAR is a protein tyrosine phosphatase (PTPase) with a cell adhesion molecule-like extracellular receptor region. The structure of LAR hinted at its involvement in the regulation of tyrosine phosphorylation through cell-cell or cell-matrix interactions. We show
Robert A Mooney et al.
Current topics in medicinal chemistry, 3(7), 809-819 (2003-04-08)
The leukocyte common antigen-related protein, LAR, is a receptor-like protein tyrosine phosphatase (PTP) which has a wide tissue distribution. Post-translational processing cleaves the proprotein into two non-covalently associated subunits, an extracellular subunit resembling a cell adhesion molecule with three immunoglobulin-like
Mélanie J Chagnon et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 82(6), 664-675 (2005-01-28)
The protein tyrosine phosphatases (PTPs) have emerged as critical players in diverse cellular functions. The focus of this review is the leukocyte common antigen-related (LAR) subfamily of receptor PTPs (RPTPs). This subfamily is composed of three vertebrate homologs, LAR, RPTP-sigma
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