推荐产品
生物源
mouse
共軛
unconjugated
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
VPS4-110, monoclonal
形狀
buffered aqueous solution
分子量
antigen ~50 kDa
物種活性
mouse, canine, bovine, human, rat
濃度
~1.0 mg/mL
技術
immunoprecipitation (IP): suitable
western blot: 1-2 μg/mL using whole extracts of mouse 3T3 or human HEK-293 cells.
同型
IgG1
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... VPS4A(27183)
mouse ... Vps4a(116733)
rat ... Vps4a(246772)
一般說明
Monoclonal Anti-VPS4A (mouse IgG1 isotype) is derived from the hybridoma VPS4-110 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human VPS4A, conjugated to KLH.
Vacuolar-protein-sorting factor 4A (VPS4A) is an AAAtype ATPase, encoded by the gene mapped to human chromosome 16q22.1. The encoded protein is a member of vacuolar sorting protein family. The protein is characterized by a canonical AAA ATPase cassette followed by an N-terminal MIT (microtubule interacting and trafficking) domain.
應用
Monoclonal Anti-VPS4A antibody has been used in
- immunoblotting
- immunoprecipitation
- immunolabelling
生化／生理作用
Vacuolar-protein-sorting factor 4A (VPS4A) plays a vital role in lysosomal/endosomal membrane trafficking. It is also involved in the regulation of exosome biogenesis. Downregulated expression of the gene leads to the development of hepatocellular carcinoma (HCC). Thus, VPS4 is considered to be an effective tumor suppressor for HCC. Mutation of the gene leads to defective multivesicular body formation.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Disruption of Neurexin 1 Associated with Autism Spectrum Disorder
Kim HG
American Journal of Human Genetics, 82, 199-207 (2008)
A fourth locus for autosomal dominant hypercholesterolemia maps at 16q22.1
Marques-Pinheiro A
European Journal of Human Genetics, 18, 1236-1242 (2010)
Vps4A Functions as a Tumor Suppressor by Regulating the Secretion and Uptake of Exosomal MicroRNAs in Human Hepatoma Cells
Wei JX
Hepatology, 61, 1284-1294 (2015)
Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A
Scott A
Proceedings of the National Academy of Sciences of the USA, 102, 13813-13818 (2005)
Triggered recruitment of ESCRT machinery promotes endolysosomal repair
Skowyra M L, et al.
Science, 360(6384), eaar5078-eaar5078 (2018)
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