推荐产品
生物源
mouse
共軛
unconjugated
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
GR6, monoclonal
形狀
buffered aqueous solution
分子量
antigen ~55 kDa
物種活性
human
濃度
~1.0 mg/mL
技術
immunoprecipitation (IP): suitable
western blot: 2-4 μg/mL using whole extracts of human HepG2 cells.
同型
IgG1
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... GSR(2936)
一般說明
Monoclonal Anti-Glutathione Reductase (mouse IgG1 isotype) is derived from the hybridoma GR6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a human Glutathione reductase recombinant protein. Glutathione reductase is a homodimeric enzyme containing one FAD molecule and NADPH binding domain per subunit. This gene is located on human chromosome 8p.
免疫原
mice immunized with a human Glutathione reductase recombinant protein. The corresponding proteins in rat and mouse share 86% and 85% homology, respectively.
應用
Monoclonal Anti-Glutathione Reductase antibody produced in mouse has been used in:
- immunohistochemical
- immunofluorescence studies
- immunoblotting
- immunoprecipitation
生化／生理作用
Glutathione reductase (GR) is a ubiquitous flavoenzyme involved in protecting cells from stress. GR catalyses the reduction of oxidized glutathione (GSSG) to glutathione (GSH). It is an essential component of the glutathione redox cycle, which maintains adequate levels of reduced cellular GSH. GSH serves as an antioxidant and also as an electron donor for glutathione peroxidases and a substrate for glutathione-S-transferases.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Inherited glutathione reductase deficiency and Plasmodium falciparum malaria?a case study
Gallo V, et al.
Testing, 4(10), e7303-e7303 (2009)
Inverted tandem duplication of 8p12-p23. 1 in a child with increased activity of glutathione reductase.
Nevin NC, et al.
Journal of medical Genetics, 27(2), 135-136 (1990)
Electrostatic control of the isoalloxazine environment in the two-electron reduced states of yeast glutathione reductase
Picaud T and Desbois A
The Journal of Biological Chemistry, 277(35), 31715-31721 (2002)
The effect of glucagon-like peptide-1 in the management of diabetes mellitus: cellular and molecular mechanisms.
Lotfy M, et al.
Cell and Tissue Research, 358(2), 343-358 (2014)
B Wu et al.
Clinical and experimental immunology, 176(3), 438-451 (2014-02-18)
Innate immune and inflammatory responses are involved in myocardial ischaemia/reperfusion (I/R) injury. Interleukin (IL)-37 is a newly identified member of the IL-1 family, and functions as a fundamental inhibitor of innate immunity and inflammation. However, its role in myocardial I/R
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