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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
human
技術
immunohistochemistry: suitable
indirect immunofluorescence: suitable
western blot: 500-3000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... CDT1(81620)
一般說明
Chromatin licensing and DNA replication factor 1/Cdc10-dependent transcript 1 (CDT1), a G1-specific cell-cycle factor, belongs to the pre-replication complex (pre-RC). The CDT1 gene is located on the human chromosome 16q24.3.
免疫原
Synthetic peptide containing a sequence corresponding to a region within amino acids 448 and 490 (Q9H211) of CDT1 according to AAH08676
應用
Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-P: 1:100-1:1000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
生化／生理作用
Chromatin licensing and DNA replication factor 1/Cdc10-dependent transcript 1 (CDT1) is involved in minichromosome maintenance (MCM) loading at the G1 phase of the cell cycle. It plays a key role in origin licensing in eukaryotic cells. It is a DNA replication protein that stimulates the production of pre-replicative complexes and replication in the next cell cycle by accumulating at the end of the cell cycle. The CDT1 gene mutation can cause Meier–Gorlin syndrome, a type of primordial dwarfism.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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訊號詞
Warning
危險聲明
危險分類
Aquatic Chronic 3 - Skin Sens. 1
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Andrea Ballabeni et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(30), E2848-E2853 (2013-07-10)
Cdc10-dependent transcript 1 (Cdt1) is an essential DNA replication protein whose accumulation at the end of the cell cycle promotes the formation of pre-replicative complexes and replication in the next cell cycle. Geminin is thought to be involved in licensing
Cdt1 interactions in the licensing process: a model for dynamic spatiotemporal control of licensing.
Georgia Xouri et al.
Cell cycle (Georgetown, Tex.), 6(13), 1549-1552 (2007-06-30)
Within each cell cycle, a cell must ensure that the processes of selection of replication origins (licensing) and initiation of DNA replication are well coordinated to prevent reinitiation of DNA replication from the same DNA segment during the same cell
Zannel Blanchard et al.
PloS one, 9(4), e95663-e95663 (2014-05-03)
Breast cancer is the second leading cause of cancer-related deaths in women. Triple negative breast cancer (TNBC) is an aggressive subtype that affects 10-25% mostly African American women. TNBC has the poorest prognosis of all subtypes with rapid progression leading
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