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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
mouse, human
技術
ELISA: suitable
flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 500-3000
NCBI登錄號
UniProt登錄號
應用
research pathology
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... GPC1(2817)
一般說明
Glypican 1 (GPC1) is located at 2q37.3 on the human chromosome. It belongs to the family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan. GPC1 is localized in the vascular system. GPC1 consists of an N-terminal secretory signal peptide, 14 conserved cysteine residues, a heparan sulfate (HS) attachment domain near the C terminus and a hydrophobic domain for attachment of the glycosylphosphatidylinositol (GPI) at the C terminus.
免疫原
Recombinant protein encompassing a sequence within the center region of human Glypican 1.
應用
Anti-GPC1 antibody produced in rabbit has been used in flow cytometry and immunostaining.
生化／生理作用
Glypican 1 (GPC1) plays an important role in cell growth, differentiation and morphogenesis. It also plays a role in cell migration, adhesion, anti-coagulation, lipoprotein metabolism and modulation of growth factors. GPC1 exhibits chaperone-like activity by restoring the binding activity of oxidized VEGF165 (vascular endothelial growth factors-165). Overexpression of GPC1 results in over accumulation of β-amyloid protein (Aβ) in the Alzheimer′s disease (AD) brain. Mutation in this gene is associated with Niemann-Pick C1 disease.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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訊號詞
Warning
危險聲明
危險分類
Aquatic Chronic 3 - Skin Sens. 1
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Characterization of Slit protein interactions with glypican-1
Ronca F, et al.
Test, 276(31), 29141-29147 (2001)
Glypican-1 as an Abeta binding HSPG in the human brain: Its localization in DIG domains and possible roles in the pathogenesis of Alzheimer?s disease
Watanabe N, et al.
Faseb Journal, 18(9), 1013-1015 (2004)
Molecular delineation of deletions on 2q37. 3 in three cases with an Albright hereditary osteodystrophy-like phenotype
Shrimpton A E, et al.
Clinical Genetics, 66(6), 537-544 (2004)
Crystal Structure of N-Glycosylated Human Glypican-1 Core Protein structure of Two Loops Evolutionarily Conserved in Vertebrate Glypican-1
Svensson G, et al.
The Journal of biological chemistry, 287(17), 14040-14051 (2012)
Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165
Gengrinovitch S, et al.
Test, 274(16), 10816-10822 (1999)
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