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![[KD Validated]Anti-PCSK9 Antibody, clone 9L4U5, Rabbit Monoclonal](/deepweb/assets/sigmaaldrich/product/images/287/260/cdc087a1-d8df-45f5-b520-65479f938aa1/640/cdc087a1-d8df-45f5-b520-65479f938aa1.jpg)
生物源
goat
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
mouse, human, rat
技術
indirect ELISA: suitable
western blot: suitable
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... PCSK9(255738)
一般說明
PCSK9 (proprotein convertase subtilisin/Kexin Type 9) codes for a secretory serine protease predominantly expressed in liver and intestine. The PCSK9 gene is mapped to human chromosome 1p32.3 and is highly polymorphic.. PCSK9 is also expressed in vascular smooth muscle cells.
免疫原
Peptide with sequence TRFHRQASKCDSHGT, from the internal region of the protein sequence according to NP_777596.2
生化／生理作用
PCSK9 (proprotein convertase subtilisin/Kexin Type 9) promotes lysosomal degradation of LDLR (low density lipoprotein receptor), VLDL (very low density lipoprotein receptor) and LRP (LDL related protein) to cause clearance of plasma cholesterol. On the other hand, PCSK9 also stimulates the release of chylomicron in intestinal cells. Lower intracellular cholesterol and mutations such as gain of function stimulates the expression of PCSK9. Autosomal dominant hypercholesterolemia is a result of high LDLR-degradation caused due to mutated PCSK9. PCSK9 is known to prevent the entry and replication of hepatitis C virus. PCSK9 expression is observed in atherosclerotic plaques.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Circulating Levels of Proprotein Convertase Subtilisin/Kexin Type 9 and Arterial Stiffness in a Large Population Sample: Data From the Brisighella Heart Study.
Ruscica M, et al.
Journal of the American Heart Association, 6(5), e005764-e005764 (2017)
The elevation of plasma concentrations of apoB-48-containing lipoproteins in familial hypercholesterolemia is independent of PCSK9 levels
Drouin-Chartier J P, et al.
Lipids in Health and Disease, 16(1), 119-119 (2017)
From proprotein convertase subtilisin/kexin type 9 to its inhibition: state-of-the-art and clinical implications.
Navarese E P, et al.
European heart journal. Cardiovascular pharmacotherapy, 2(1), 44-53 (2015)
Malaria severity: Possible influence of the E670G PCSK9 polymorphism: A preliminary case-control study in Malian children.
Arama C, et al.
PLoS ONE, 13(2), e0192850-e0192850 (2018)
What is the impact of PCSK9 rs505151 and rs11591147 polymorphisms on serum lipids level and cardiovascular risk: a meta-analysis.
Qiu C, et al.
Lipids in Health and Disease, 16(1), 111-111 (2017)
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