一般說明
Pyruvate carboxylase (PC), a mitochondrial enzyme, is a nuclear-encoded protein. Expression of biologically active PC is seen in skeletal muscle. PC is a homotetramer in vertebrates, with each subunit having biotin carboxylase (BC), carboxyltransferase (CT), and biotin-carboxyl carrier protein (BCCP) domains and a covalently linked biotin cofactor. The PC gene is located on human chromosome 11q13.2.
免疫原
Peptide with sequence C-KFKEVKKAYVEANQ from the internal region of the protein sequence according to NP_000911.2; NP_001035806.1; NP_071504.2.
應用
Anti-Pyruvate Carboxylase antibody produced in goat has been used in immunoblotting.
生化／生理作用
Pyruvate carboxylase (PC) enzyme converts pyruvate to oxaloacetate. It plays an important role in mitochondrial metabolism in all cells and its absence is lethal. Expression of PC is highly essential for the development of pulmonary tumors. PC is involved in the pulmonary tropism of metastatic breast cancer. It is associated with the pathogenesis of ovarian cancer. Lower expression of PC can block cell proliferation, progression of the cell cycle, migration, and invasion of cells.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Hongkai Shang et al.
Aging, 12(21), 21874-21889 (2020-11-13)
The aim of this study was to explore prognosis-related biomarkers and underlying mechanisms during ovarian carcinoma progression and development. mRNA expression profiles and GSE49997 dataset were downloaded. Survival analyses were performed for genes with high expression levels. Expression level of
Lisa Kappler et al.
American journal of physiology. Endocrinology and metabolism, 317(2), E374-E387 (2019-06-19)
Mitochondria are dynamic organelles with diverse functions in tissues such as liver and skeletal muscle. To unravel the mitochondrial contribution to tissue-specific physiology, we performed a systematic comparison of the mitochondrial proteome and lipidome of mice and assessed the consequences
Laure Perrin-Cocon et al.
Communications biology, 4(1), 217-217 (2021-02-18)
During the cancerous transformation of normal hepatocytes into hepatocellular carcinoma (HCC), the enzyme catalyzing the first rate-limiting step of glycolysis, namely the glucokinase (GCK), is replaced by the higher affinity isoenzyme, hexokinase 2 (HK2). Here, we show that in HCC
商品
This is an article about how proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metabolites away from mitochondrial oxidative phosphorylation, many tumor cells exhibit increased mitochondrial activity.
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