推荐产品
生物源
goat
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
canine, rat, mouse, human
技術
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... G6PD(2539)
一般說明
The gene encoding G6PD (glucose-6-phosphate dehydrogenase) is mapped to human chromosome Xq28 and spans 16.2 kb. One G6PD monomer is composed of 515 amino acids with a predicted molecular weight of 59,256 Da. The active enzyme exists as a dimer and contains an NADP molecule tightly bound to it.
免疫原
Peptide with sequence C-STNSDDVRDEKVK from the internal region of the protein sequence according to NP_000393.4 ; NP_001035810.1.
生化／生理作用
G6PD (glucose-6-phosphate dehydrogenase) enzyme catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconolactone, reducing NADP to NADPH. It therefore, catalyzes the first step of hexose monophosphate pathway (HMP). As it oxidizes glucose-6-phosphate, it confers protection against oxidative damage in erythrocytes. Its deficiency is highly heterogeneous, with around 190 variants being reported. The deficiency of G6PD was discovered while studying hemolytic anemia. G6PD also results in hereditary nonspherocytic hemolytic anemia.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
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訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
G6PD deficiency.
Beutler E.
Blood, 23-167 (1978)
Alphaxard Manjurano et al.
PLoS genetics, 11(2), e1004960-e1004960 (2015-02-12)
X-linked Glucose-6-phosphate dehydrogenase (G6PD) A- deficiency is prevalent in sub-Saharan Africa populations, and has been associated with protection from severe malaria. Whether females and/or males are protected by G6PD deficiency is uncertain, due in part to G6PD and malaria phenotypic
Glucose-6-phosphate dehydrogenase deficiency: a historical perspective.
Beutler E
Blood, 111(1), 16-24 (2008)
Saúl Gómez-Manzo et al.
International journal of molecular sciences, 15(11), 21179-21201 (2014-11-20)
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency worldwide, causing a wide spectrum of conditions with severity classified from the mildest (Class IV) to the most severe (Class I). To correlate mutation sites in the G6PD with the
E Y Chen et al.
Human molecular genetics, 5(5), 659-668 (1996-05-01)
DNA comprising 219 447 bp was sequenced in nine cosmids and verified at > 99.9% precision. Of the standard repetitive elements, 187 Alus make up 20.6% of the sequence, but there were only 27 MERs (2.9%) and 17 L1 fragments
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