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生物源
goat
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
human, mouse, rat
技術
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
基因資訊
human ... FOXA2(3170)
一般說明
Forkhead box A2 (FOXA2), also known as hepatocyte nuclear factor 3-β (HNF3-β), is encoded by the gene mapped to human chromosome 20p11.21. It is expressed in the liver, pancreas, intestine, and lungs. FOXA2 is a member of forkhead box (FOX) gene family and is characterized by a DNA binding “winged helix domain”.
免疫原
Peptide with sequence C-GVYSRPIMNSS from the C Terminus of the protein sequence according to NP_068556.1; NP_710141.1.
生化／生理作用
Forkhead box A2 (FOXA2) or HNF3β is associated with embryonic formation of the primitive streak and endoderm. It also plays an important role in airway epithelial differentiation and is extensively expressed in type II pneumocytes. Decreased expression of FOXA2 is observed in lung cancer and non-small-cell lung cancer (NSCLC). FOXA2 plays a vital role in normal pancreatic β-cell function and aberration in the expression of the gene leads to hyperinsulinemic hypoglycemia. It also has an essential role in pancreatic α-cell differentiation. FOXA2 acts a regulator of the network of genes associated with intestinal epithelial cell function. Increased expression of FOXA2 in MKN-45 cells (human gastric cancer cell line) elevates E-cadherin expression and inhibits gastric cancer cell migration and invasion and therefore, FOXA2 is expressed at low levels in gastric adenocarcinoma tissues.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Frequent downregulation of the transcription factor Foxa2 in lung cancer through epigenetic silencing.
Basseres DS
Lung Cancer (2012)
[Down-expression of FOXA2 in gastric adenocarcinoma].
Zhang Z
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology (2015)
FOXA2 regulates a network of genes involved in critical functions of human intestinal epithelial cells.
Gosalia N
Physiological Genomics (2015)
Foxa2 is required for the differentiation of pancreatic alpha-cells.
Developmental Biology (2005)
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