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Merck
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主要文件

SAB2500307

Sigma-Aldrich

Anti-DGAT1 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

别名:

Anti-ACAT related gene product 1, Anti-ARGP1, Anti-Acyl coenzyme A:cholesterol acyltransferase related gene 1, Anti-DGAT, Anti-Diacylglycerol O-acyltransferase homolog 1

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

goat

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

物種活性

human, rat, canine, mouse

技術

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... DGAT1(8694)

相关类别

一般說明

Diacylglycerol O-acyltransferase 1 (DGAT1) is a 500kDa, hydrophobic protein, which is highly expressed in the skin, mammary gland, adipose tissue, small intestine and testis. The gene encoding it is localized on human chromosome 8q24.3.

免疫原

Peptide with sequence C-QNSMKPFKDMDYS from the internal region of the protein sequence according to NP_036211.1.

應用

Anti-DGAT1 antibody produced in goat has been used in Western blotting.

生化/生理作用

Diacylglycerol O-acyltransferase 1 (DGAT1) has a role in the biosynthesis of triglycerides. Mutations in the gene have been linked to congenital diarrhea and protein-losing enteropathy. DGAT1 is also associated with metabolic disorders like diabetes and obesity.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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访问文档库

The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters
Chi-Liang
Journal of Lipid Research (2005)
Iván P Uray et al.
Molecular pharmacology, 81(2), 228-238 (2011-11-05)
Synthetic rexinoids effectively suppress both estrogen receptor-positive and estrogen receptor-negative mammary tumors in animal models, which makes them prime candidates for a novel class of cancer-preventive agents. When used in combination with chemotherapy for non-small-cell lung cancer, the rexinoid bexarotene
Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea.
Gluchowski NL
Journal of Lipid Research (2017)
Prolonged silencing of diacylglycerol acyltransferase-1 induces a dedifferentiated phenotype in human liver cells.
Chang S
Journal of Cellular and Molecular Medicine (2016)
Cancer-Preventive Rexinoid Modulates Neutral Lipid Contents of Mammary Epithelial Cells through a Peroxisome Proliferator-Activated Receptor ?-Dependent Mechanism
Ivan P
Molecular Pharmacology (2012)

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