推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
36 kDa
物種活性
human, rat, guinea pig, horse, bovine, mouse, dog
濃度
0.5 mg - 1 mg/mL
技術
western blot: suitable
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... MAFB(9935)
一般說明
MAF bZIP transcription factor B (MAFB) is encoded by the gene mapped to human chromosome 20q12. The encoded protein is a member of the maf oncogene family and is ubiquitously expressed in variety of tissues. MAFB is a 311 amino acid protein characterized with a typical basic leucine zipper (bZIP) domain in its C-terminal region.
免疫原
Synthetic peptide directed towards the N terminal region of human MAFB
生化／生理作用
MAF bZIP transcription factor B (MAFB) has been implicated in the development of the hindbrain structures, thymus, interneurons, pancreatic islet cells and the hematopoietic system. In mouse, it helps in lip and palate development. MAFB regulates lineage-specific gene expression by suppressing the Ets-1-mediated transcription. The encoded protein plays an essential role in islet α-cell function. In addition, MAFB also regulates genes involved in both endocrine α- and β-cell differentiation. The protein acts as a modulator and marker of adipose tissue inflammation. Mutations in the gene is associated with the development of multicentric carpo-tarsal osteolysis (MCTO).
序列
Synthetic peptide located within the following region: APQGSATAAEPQPGDPARASQDSADPQAPAQGNFRGSWDCSSPEGNGSPE
外觀
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
Beaty TH
Nature Genetics, 42, 525-529 (2010)
MafB Is an Interaction Partner and Repressor of Ets-1 That Inhibits Erythroid Differentiation
Sieweke MH
Cell, 85, 49-60 (1996)
MafB, a New Maf Family Transcription Activator That Can
Associate with Maf and Fos but Not with Jun
Kataoka K
Molecular and Cellular Biology, 14, 7581-7591 (1994)
The identification of MAFB mutations in eight patients with multicentric carpo-tarsal osteolysis supports genetic homogeneity but clinical variability.
Mehawej C
American Journal of Medical Genetics. Part A, 161A, 3023-3029 (2013)
MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.
Artner I
Diabetes, 55, 297-304 (2006)
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