推荐产品
生物源
mouse
品質等級
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
9E10, monoclonal
形狀
buffered aqueous solution
技術
western blot: 1:2,000
同型
IgG1
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
一般說明
The cellular myelocytomatosis (c-myc) gene is mapped to human chromosome 8q24. It is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. c-myc is a member of MYC gene family.c-Myc gene codes for basic helix-loop-helix/leucine zipper (bHLH/LZ) transcription factor that regulates the G1-S cell cycle transition.
應用
MONOCLONAL ANTI-MYC TAG antibody produced in mouse has been used in Western blotting.
生化／生理作用
The cellular myelocytomatosis (c-myc) oncogene plays a vital role in cellular proliferation, differentiation, apoptosis and acts as transcriptional regulator of gene expression. c-myc expression is essential and sufficient to assist most of the cells to enter DNA synthetic (S) phase of the cell cycle. The encoded protein plays a crucial role in vasculogenesis and angiogenesis during cancer development and progression. c-myc interacts with its binding partner Max and activates the transcription of growth promoting genes such as cyclin D2 and ornithine decarboxylase. It also represses the transcription of multiple genes, especially p21 and p27, by binding to the transcription initiator element (Inr) in a complex with Max and either Sp1 or Miz1. Overexpression of MYC in DLBCL (diffuse large B-cell lymphoma) results in poor outcome and invasive treatment when medicated with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP).
外觀
Supplied in PBS with 0.09% (W/V) sodium azide
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Long noncoding RNA MALAT1 promotes hepatic steatosis and insulin resistance by increasing nuclear SREBP-1c protein stability
Caifeng Yan, et al.
Scientific Reports (2016)
Over-expression of the c-myc proto-oncogene in colorectal carcinoma.
Smith DR, et al.
British Journal of Cancer, 68(2) (1993)
Zixing Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(19), E4522-E4531 (2018-04-25)
Abscisic acid (ABA) plays essential roles in plant development and responses to environmental stress. ABA induces subcellular translocation and degradation of the guanine nucleotide exchange factor RopGEF1, thus facilitating ABA core signal transduction. However, the underlying mechanisms for ABA-triggered RopGEF1
MAPK signal pathways in the regulation of cell proliferation in mammalian cells.
Zhang W, et al.
Cell Research, 12(1), 9-18 (2002)
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity.
Gordan JD,et al.
Cancer Cell, 11(4), 335-347 (2007)
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