推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
human
技術
immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CCL19(6363)
一般說明
CCL19 (C-C motif chemokine ligand 19) gene is mapped in human chromosome 9p13.3. CCL19 is constantly expressed in secondary lymphoid tissue.
The gene for CCL19 is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. CCL19 may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.
免疫原
CCL19 (NP_006265, 11-41)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human CCL19.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human CCL19.
生化／生理作用
CCL19 (C-C motif chemokine ligand 19) is an homeostatic chemokine, involved in adaptive immune system. CCL19 recruits monocytes, macrophages, antigen presenting dendritic cells and naïve T-cells to secondary lymphoid organs by activation of CCR7 (C-C motif chemokine receptor 7). It controls cell migration in inflammation reaction and dysregulated angiogenesis in many types of diseases. CCL19 is upregulated in human atherosclerotic lesions. CCL19 is involved in the development of various inflammatory disorders such as asthma, atherosclerosis and rheumatoid arthritis. CCL19 might also be associated with the pathogenesis of rickettsiae infection.
外觀
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Albert Zlotnik et al.
Genome biology, 7(12), 243-243 (2007-01-05)
The human chemokine superfamily currently includes at least 46 ligands, which bind to 18 functionally signaling G-protein-coupled receptors and two decoy or scavenger receptors. The chemokine ligands probably comprise one of the first completely known molecular superfamilies. The genomic organization
Elisabeth Astrup et al.
BMC infectious diseases, 14, 70-70 (2014-02-11)
Based on their essential role in concerting immunological and inflammatory responses we hypothesized that the homeostatic chemokines CCL19 and CCL21 may play a pathogenic role in rickettsiae infection. Serum levels of CCL19 and CCL21 in patients with R. africae and
Christopher T Veldkamp et al.
Biochemistry, 54(27), 4163-4166 (2015-06-27)
CCL19 and CCL21 are chemokines involved in the trafficking of immune cells, particularly within the lymphatic system, through activation of CCR7. Concurrent expression of PSGL-1 and CCR7 in naive T-cells enhances recruitment of these cells to secondary lymphoid organs by
Hong-Ren Yu et al.
Journal of cellular physiology, 230(9), 2120-2127 (2015-02-07)
Resistin may be an important link between obesity and diabetes. Recent studies have suggested an association between resistin and atherogenic processes. In addition, CCL19 is highly expressed in human atherosclerotic lesions. The interplays among resistin, CCL19, and shear stress in
Yang Qin et al.
BMC musculoskeletal disorders, 15, 316-316 (2014-09-28)
It is well-documented that both chemokine (C-C motif) ligand 19 (CCL19) and 21 (CCL21) mediate cell migration and angiogenesis in many diseases. However, these ligands' precise pathological role in ankylosing spondylitis (AS) has not been elucidated. The objective of this
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