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生物源
rabbit
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~20 kDa
物種活性
human
技術
indirect immunofluorescence: suitable
western blot: 1:500-1:2,000
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... ARPC4(10093)
一般說明
Actin related protein 2/3 complex, subunit 4 (ARPC4) is mapped to human chromosome 3p25.3. It is part of the ARP2/3 complex which connects this complex to the mother filament.
免疫原
synthetic peptide corresponding to amino acids 26-40 of human ARPC4
應用
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
生化／生理作用
Actin related protein 2/3 complex, subunit 4 (ARPC4) in plants is crucial for action dynamics and cordinates the tip growth and movement. It is highly expressed in most of the pancreatic carcinoma and may regulate cancer cell migration. It interacts with mycobacterial protein Rv1626 and its expression in Mycobacterium tuberculosis impacts its survival and infection profile, making it an effective anti-tuberculosis drug candidate.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Expression of the ARPC4 subunit of human Arp2/3 severely affects Mycobacterium tuberculosis growth and suppresses immunogenic response in murine macrophages
Ghosh A, et al.
Testing, 8(7), e69949-e69949 (2013)
The role of ARPC4 in tip growth and alignment of the polar axis in filaments of Physcomitrella patens
Perroud PF and Quatrano RS
Cell Motility and the Cytoskeleton, 63(3), 162-171 (2006)
Silencing of the ARP2/3 complex disturbs pancreatic cancer cell migration
Rauhala HE, et al.
Anticancer Research, 33(1), 45-52 (2013)
3p- syndrome defines a hearing loss locus in 3p25.3
McCullough BJ, et al.
Hearing Research, 224(1-2), 51-60 (2007)
Chiara Galloni et al.
The Journal of cell biology, 220(8) (2021-06-10)
The mechanisms regulating the disassembly of branched actin networks formed by the Arp2/3 complex still remain to be fully elucidated. In addition, the impact of Arp3 isoforms on the properties of Arp2/3 are also unexplored. We now demonstrate that Arp3
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