推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~21 kDa
物種活性
human
技術
western blot: 1:500-1:2,000
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... RNF4(6047)
一般說明
Really interesting new gene (RING ) finger protein 4 (RNF4) gene encodes ubiquitin E3 ligase, an enzyme widely expressed in many tissues. The protein contains a RING (really interesting new gene) finger domain and around three small ubiquitin-related modifier (SUMO)-interaction motifs. RNF4 is mapped to human chromosome 4p16.3.
免疫原
synthetic peptide corresponding to amino acids 176-190 of human RNF4
應用
Anti-RNF4 (176-190) antibody produced in rabbit has been used in western blotting analysis.
生化／生理作用
Really interesting new gene (RING ) finger protein 4 (RNF4) catalyzes the ubiquitylation of proteins associated with small ubiquitin-related modifier (SUMO). Rnf4 is involved in DNA repair, in transcription and chromatin regulation. It is also associated with the process of hematopoiesis. RNF4 is implicated in acute promyelocytic leukemia, acute myeloid leukemia, Fanconi anemia and aplastic anemia.
標靶描述
RNF4 (176-190), ring finger protein 4. encodes a protein that contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells
Wang WF, et al.
Nature Communications, 8(1), 363-363 (2017)
RNF4 is a growth inhibitor expressed in germ cells but not in human testicular tumors
Pero R, et al.
The American Journal of Pathology, 159(4), 1225-1230 (2001)
RNF4 regulates zebrafish granulopoiesis through the DNMT1-C/EBPalpha axis
Wang L, et al.
Faseb Journal, 32(9), 4930-4940 (2018)
E1B-55K-mediated regulation of RNF4 SUMO-targeted ubiquitin ligase promotes human adenovirus gene expression
Muncheberg S, et al.
Journal of Virology, 92(13), e00164-e00118 (2018)
Wen-Fang Wang et al.
Nature communications, 8(1), 363-363 (2017-08-27)
B lymphocyte-induced maturation protein-1 (Blimp-1) ensures B-cell differentiation into the plasma cell stage, and its instability constitutes a crucial oncogenic element in certain aggressive cases of activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL). However, the underlying degradation mechanisms and
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