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S9311

Sigma-Aldrich

SIB 1893

>99%, solid

别名:

[E]-2-Methyl-6-[2-phenylethenyl]pyridine

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About This Item

经验公式（希尔记法）:
C14H13N
CAS号:
7370-21-0
分子量:
195.26
MDL號碼:
MFCD02262120
分類程式碼代碼:
12352200
PubChem物質ID:
24278718
NACRES:
NA.77

品質等級

100

化驗

>99%

形狀

solid

溶解度

DMSO: 18 mg/mL

儲存溫度

2-8°C

SMILES 字串

Cc1cccc(\C=C\c2ccccc2)n1

InChI

1S/C14H13N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-11H,1H3/b11-10+

InChI 密鑰

SISOFUCTXZKSOQ-ZHACJKMWSA-N

基因資訊

human ... GRM1(2911) , GRM5(2915)

應用

SIB 1893 may be used in mGluR5 metabotropic glutamate receptor-mediated cell signaling studies.

生化／生理作用

SIB 1893 non-competitively inhibits glutamate-induced increase in Ca2+ at human metabotropic glutamate receptor 1 (hmGluR1).1 It also acts as a positive allosteric modulator of hmGluR4.2
Selective and noncompetitive mGlu5 metabotropic glutamate receptor antagonist.

特點和優勢

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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Jesper Mosolff Mathiesen et al.
British journal of pharmacology, 138(6), 1026-1030 (2003-04-10)
We have identified 2-methyl-6-(2-phenylethenyl)pyridine (SIB-1893) and 2-methyl-6-phenylethynyl pyridine hydrochloride (MPEP) as positive allosteric modulators for the hmGluR4. SIB-1893 and MPEP enhanced the potency and efficacy of L-2-amino-4-phophonobutyrate (L-AP4) in guanosine 5'-O-(3-[(35)S]thiotriphosphate ([(35)S]GTPgammaS) binding and efficacy in cAMP studies. These effects
M A Varney et al.
The Journal of pharmacology and experimental therapeutics, 290(1), 170-181 (1999-06-25)
Cell lines expressing the human metabotropic glutamate receptor subtype 5a (hmGluR5a) and hmGluR1b were used as targets in an automated high-throughput screening (HTS) system that measures changes in intracellular Ca2+ ([Ca2+]i) using fluorescence detection. This functional screen was used to

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