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Merck

S7049

Sigma-Aldrich

D-鞘氨醇

synthetic

别名:

4-鞘氨醇, 反式-D--2-氨基-4-十八烯-1,3-二醇, (2S,3R,4E)-2-氨基-4-十八烯-1,3-二醇

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About This Item

经验公式(希尔记法):
C18H37NO2
CAS号:
分子量:
299.49
Beilstein:
1727294
EC號碼:
MDL號碼:
分類程式碼代碼:
12352211
PubChem物質ID:
NACRES:
NA.77

生物源

synthetic

品質等級

化驗

≥98% (TLC)

形狀

powder

mp

74.2-78.1 °C

溶解度

chloroform: complete 20 mg/mL, clear, colorless

脂質類型

sphingolipids

儲存溫度

−20°C

SMILES 字串

OC[C@@](N)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCC

InChI

1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1

InChI 密鑰

WWUZIQQURGPMPG-KRWOKUGFSA-N

基因資訊

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應用

已研究了 D-Sphingosine(合成的)对真菌莱氏野村菌的发芽活性的影响。8

生化/生理作用

细胞膜的一种组成部分。神经酰胺的前体。蛋白激酶 C 的选择性抑制剂,但不抑制蛋白激酶  A 或肌球蛋白轻链激酶。钙调蛋白依赖性酶的抑制剂。
鞘氨醇的天然异构体

危險聲明

防範說明

危險分類

Aquatic Chronic 4

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Nature chemical biology, 5(7), 508-514 (2009-06-16)
Though glycosphingolipids have great potential as therapeutics for cancer, HIV, neurodegenerative diseases and auto-immune diseases, both extensive study of their biological roles and development as pharmaceuticals are limited by difficulties in their synthesis, especially on large scales. Here we addressed
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