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Merck

S3007

Sigma-Aldrich

水杨酸钠

ReagentPlus®, ≥99.5% (titration)

别名:

2-羟基苯甲酸 钠盐, 水杨酸 钠盐, 钠 2-羟苯甲酸

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About This Item

线性分子式:
HOC6H4COONa
CAS号:
分子量:
160.10
Beilstein:
3732792
EC號碼:
MDL號碼:
分類程式碼代碼:
12352302
PubChem物質ID:
NACRES:
NA.25

品質等級

產品線

ReagentPlus®

化驗

≥99.5% (titration)

形狀

crystalline

顏色

white

有用的pH值範圍

6.85 (26.3 °C)

mp

>300 °C (lit.)

溶解度

water: 575.7 g/L at 25 °C (77 °F)

SMILES 字串

[Na+].Oc1ccccc1C([O-])=O

InChI

1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1

InChI 密鑰

ABBQHOQBGMUPJH-UHFFFAOYSA-M

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一般說明

水杨酸钠是阿司匹林中的活性成分,阿司匹林是解热,消炎镇痛常用药物。大量服用水杨酸钠会引起暂时听力丧失和耳鸣。使用水杨酸钠长期治疗会长期降低耳蜗分泌,降低体内化合物活性电位幅度和体外神经退化。杏仁外侧核水杨酸钠处理后会改变音调和兴奋性,导致听觉皮层过度活动。水杨酸钠能够减弱细胞内-Finkel−Biskis−Jinkins鼠成骨肉瘤病毒(c-fos)表达和海马区域 δ-FosB蛋白质,影响空间记忆和学习。水杨酸钠影响大脑齿状回区域神经发生。

應用

水杨酸钠可用于:
  • 诱导大鼠耳鸣,高敏样行为以及和杏仁体直接融合,检测区域场电位。
  • 通过脉冲前抑制行为(PPI),来诱导和确定耳鸣。通过Morris水迷宫测试确定它对对于学习和记忆的抑制作用,以及之后的大鼠基因表达研下丘背皮质的听觉反应究。
  • 用来增强γ氨基酸丁酸(GABA)能抑制,增强下丘背皮质(ICd)的听觉反应,可以通过微离子电泳技术检测。

法律資訊

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

象形圖

Health hazardExclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

208.9 °F - Pensky-Martens closed cup

閃點(°C)

98.3 °C - Pensky-Martens closed cup

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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