推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
lyophilized powder
物種活性
rat
技術
western blot: 1:200 using rat DRG lysates
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... SCN11A(11280)
mouse ... Scn11a(24046)
rat ... Scn11a(29701)
一般說明
Sodium Channel NaV1.9 is a threshold channel, that is expressed in dorsal root ganglion neurons , peripheral nociceptive neurons and visceral afferents. It is also called as SNS and NaN. It is encoded by SCN11A (sodium voltage-gated channel subunit 11) and is located on human chromosome 3p22.
免疫原
peptide CNGDLSSLDVAKVKVHND corresponding to residues 1748-1765 of rat Nav1.9. This sequence has 15/18 residues identical in mouse and 14/18 residues identical in human.
生化／生理作用
Sodium Channel NaV1.9 participates in pain at the time of inflammation. Downregulation of Nav1.9 is observed in Hirschsprung′s disease.
外觀
Lyophilized from phosphate buffered saline, pH 7.4, with 1% bovine serum albumin, and 0.05% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Biology and management of histologic transformation of indolent lymphoma
Freedman AS, et al.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, 314-20 (2005)
Decreased Nav1.9 channel expression in Hirschsprung's disease
O'Donnell AM, et al.
Journal of Pediatric Surgery, 51(9), 1458-1461 (2016)
Congenital insensitivity to pain: Fracturing without apparent skeletal pathobiology caused by an autosomal dominant, second mutation in SCN11A encoding voltage-gated sodium channel 1.9
Phatarakijnirund V, et al.
Bone, 84, 289-298 (2016)
Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability
Huang J, et al.
The Journal of Clinical Investigation, 127(7), 2805-2814 (2017)
Patrick Delmas et al.
Trends in neurosciences, 26(2), 55-57 (2003-01-22)
Voltage-gated Na(+) channels play key roles in generating and propagating action potentials. Their gating is believed to rely exclusively on changes in membrane potential. However, recent data from Blum, Kafitz and Konnerth provide direct evidence that the opening of Na(v)1.9
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