S1438

Sulindac sulfone

≥94% (HPLC), (solid or powder)

• 别名: (Z)-5-Fluoro-2-methyl-1-[p-(methylsulfonyl)benzylidene]indene-3-acetic acid
• 经验公式（希尔记法）: C₂₀H₁₇FO₄S
• CAS号: 59864-04-9
• 分子量: 372.41
• MDL號碼: MFCD01317811
• 分類程式碼代碼: 51111800
• PubChem物質ID: 24278693
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥94% (HPLC)
• 形狀: (solid or powder)
• 顏色: , Light Yellow to Dark Yellow
• 溶解度: DMSO: >25 mg/mL; ethanol: 3 mg/mL (warm); acetone: 5 mg (plus 0.1 ml)
• 起源: Merck & Co., Inc., Kenilworth, NJ, U.S.
• SMILES 字串: CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C\c3ccc(cc3)S(C)(=O)=O
• InChI: 1S/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9+
• InChI 密鑰: MVGSNCBCUWPVDA-RQZCQDPDSA-N

说明

應用

Human endothelial cells, HMEC-1 were treated with Sulindac sulfone and the effect on cell survival was studied by MTT assay.

生化／生理作用

Sulindac sulfone is non-steroidal anti-inflammatory drug and an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells^1,2 and reduces tumor burden in adenomatous polyposis patients.³

Metabolite of sulindac that inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. Inhibits the development and induces regression of premalignant adenomatous polyps.

特點和優勢

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

準備報告

Sulindac sulfone yields clear, light yellow to dark yellow solution in acetone at 50 mg/ml.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)