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生物源
human serum
品質等級
化驗
≥95% (SDS-PAGE)
形狀
buffered aqueous glycerol solution
技術
cell culture | mammalian: suitable
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
基因資訊
human ... SHBG(6462)
一般說明
Sex hormone binding globulin (SHBG) is secreted by the liver. It is also expressed in the endometrium, ovary and testis. SHBG is composed of 402 amino acids and the gene encoding it is localized on human chromosome 17p12–p13.
應用
Sex hormone binding globulin (SHBG) from human serum has been used as a spiked sample in radioimmunoassay. It may also be used to study the effects of hydroxylated estrogen metabolites (2-OH-E2 and 4-OH-E2) on the mRNA and protein expression of SHBG in MCF-7 human breast cancer cell line.
生化／生理作用
Sex hormone binding globulin (SHBG) is a dimeric plasma glycoprotein with high affinity for the gonadal steroids, testosterone and estradiol. It regulates the availability of sex steroid hormones and limits their access to target cells. SHBG also inhibits estradiol-induced proliferation of breast cancer cells. Alterations in the expression of the protein have been linked to male infertility.
外觀
Solution in 20 mM Tris-HCl, 10% Glycerol, pH 7.4
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Developmental time course of estradiol, testosterone, and dihydrotestosterone levels in discrete regions of male and female rat brain
Konkle ATM and McCarthy MM
Endocrinology, 152(1), 223-235 (2011)
Correlation between SHBG gene polymorphism and male infertility in Han population of Henan province of China
A STROBE-compliant article
A STROBE-compliant article
Yuan-rong Cui
Medicine (2017)
Sex Hormone-Binding Globulin (SHBG), estradiol and breast cancer.
Fortunati N
Molecular and Cellular Endocrinology (2010)
The ability of hydroxylated estrogens (2-OH-E2 and 4-OH-E2) to increase
of SHBG gene, protein expression and intracellular levels in MCF-7 cells
line
of SHBG gene, protein expression and intracellular levels in MCF-7 cells
line
Gregoraszczuk EL
Endocrine regulations (2011)
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