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Merck

RAB1138

Sigma-Aldrich

大鼠BDNF ELISA试剂盒

for cell culture supernatants, plasma, and serum samples

别名:

BDNF, Brain-derived neurotrophic factor

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About This Item

分類程式碼代碼:
41116158
NACRES:
NA.32

物種活性

human, rat

包裝

kit of 96 wells (12 strips x 8 wells)

技術

ELISA: suitable

輸入

sample type plasma
sample type cell culture supernatant(s)
sample type serum sample(s)

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 12 pg/ml

檢測方法

colorimetric

運輸包裝

wet ice

儲存溫度

−20°C

基因資訊

rat ... Bdnf(24225)

一般說明

脑源性神经营养因子(BDNF)基因定位于人类染色体11p14.1上。该基因编码前体蛋白proBDNF。成熟的BDNF(mBDNF)是通过proBDNF的翻译后切割合成的。
该ELISA抗体对可检测大鼠和人BDNF。其他物种尚未测定。

應用

仅供研究使用。不可用于诊断操作。
详细内容请参阅附件实验方案

生化/生理作用

脑源性神经营养因子(BDNF)参与人类的海马功能和言语情节记忆。BDNF在血管功能中也起着至关重要的作用,并通过特异性受体原肌球蛋白相关激酶B(TrkB)参与血管生成。它参与了阿尔茨海默′病的发病机制。

其他說明

本产品提供了样品检验报告。请在批号对应的文本框中输入样品一词。

象形圖

Corrosion

訊號詞

Warning

危險聲明

防範說明

危險分類

Met. Corr. 1

儲存類別代碼

8A - Combustible corrosive hazardous materials

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Jie Kang et al.
Brain sciences, 11(1) (2020-12-31)
(1) Background: Depression is one of the overwhelming public health problems. Alleviating hippocampus injury may prevent depression development. Herein, we established the chronic unpredictable mild stress (CUMS) model and aimed to investigate whether aerobic exercise (AE) could alleviate CUMS induced
Peripheral vascular reactivity and serum BDNF responses to aerobic training are impaired by the BDNF Val66Met polymorphism.
Lemos JR Jr, et al.
Physiological Genomics, 48(2), 116-123 (2015)
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.
Egan MF, et al.
Cell, 112(2), 257-269 (2003)
11p14. 1 microdeletions associated with ADHD, autism, developmental delay, and obesity.
Shinawi M, et al.
American Journal of Medical Genetics. Part A, 155(6), 1272-1280 (2011)
Monica Serra et al.
Aging, 11(11), 3851-3863 (2019-06-13)
Aging increases the risk of cancer partly through alterations in the tissue microenvironment. Time-restricted feeding (TRF) is being proposed as an effective strategy to delay biological aging. In the present studies, we assessed the effect of long-term exposure to TRF

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