跳转至内容
Merck

R2533

Sigma-Aldrich

RS-127445 hydrochloride

≥98% (HPLC), powder

别名:

2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride

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About This Item

经验公式(希尔记法):
C17H16FN3 · HCl
分子量:
317.79
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to tan

溶解度

DMSO: ≥20 mg/mL

起源

Roche

儲存溫度

2-8°C

SMILES 字串

Cl.CC(C)c1cc(nc(N)n1)-c2ccc(F)c3ccccc23

InChI

1S/C17H16FN3.ClH/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13;/h3-10H,1-2H3,(H2,19,20,21);1H

InChI 密鑰

MKJPYBJBPRFMHL-UHFFFAOYSA-N

生化/生理作用

RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.

特點和優勢

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形圖

Skull and crossbones

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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