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Merck
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R140

Sigma-Aldrich

Ro 04-6790 二盐酸盐

solid

别名:

4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide dihydrobromide

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About This Item

经验公式（希尔记法）:
C12H16N6O2S · 2HCl
CAS号:
202466-68-0
分子量:
381.28
MDL號碼:
MFCD11045584
分類程式碼代碼:
12352202
PubChem物質ID:
24278570
NACRES:
NA.77

形狀

solid

顏色

white

溶解度

DMSO: >10 mg/mL
H2O: >10 mg/mL

起源

Roche

SMILES 字串

Cl.Cl.CNc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(NC)n1

InChI

1S/C12H16N6O2S.2ClH/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9;;/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18);2*1H

InChI 密鑰

QOAXXMSJHQHSFV-UHFFFAOYSA-N

基因資訊

human ... HTR6(3362)

生化／生理作用

Selective 5-HT6 serotonin receptor antagonist.

特點和優勢

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

注意

Photosensitive

法律資訊

Manufactured and sold under license from Hoffman LaRoche.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

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A J Sleight et al.
British journal of pharmacology, 124(3), 556-562 (1998-07-01)
1. This study describes the in vitro characterization of two potent and selective 5-HT6 receptor antagonists at the rat and human recombinant 5-HT6 receptor. 2. In binding assays with [3H]-LSD, 4-amino-N-(2,6 bis-methylamino-pyrimidin-4-yl)-benzene sulphonamide (Ro 04-6790) and 4-amino-N-(2,6 bis-methylamino-pyridin-4-yl)-benzene sulphonamide (Ro
J C Bentley et al.
British journal of pharmacology, 126(7), 1537-1542 (1999-05-14)
1. The present study examined the effects of the selective 5-HT6 receptor antagonist 4-amino-N-(2, 6 bis-methylamino-pyrimidin-4-yl)-benzene sulphonamide (Ro 04-6790) on locomotor activity and unconditioned behaviour in male Sprague Dawley rats (230-300 g). 2. In non-quantified behavioural observations, animals treated with

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