PZ0185

PF-431396 水合物

≥98% (HPLC)

• 别名: N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-Methanesulfonamide hydrate
• 经验公式（希尔记法）: C₂₂H₂₁F₃N₆O₃S · xH₂O
• CAS号: 717906-29-1
• 分子量: 506.50 (anhydrous basis)
• MDL號碼: MFCD21608515
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329823759
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: off-white to blue-gray
• 溶解度: DMSO: ≥10 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: O.CN(c1ccccc1CNc2nc(Nc3ccc4NC(=O)Cc4c3)ncc2C(F)(F)F)S(C)(=O)=O
• InChI: 1S/C22H21F3N6O3S.H2O/c1-31(35(2,33)34)18-6-4-3-5-13(18)11-26-20-16(22(23,24)25)12-27-21(30-20)28-15-7-8-17-14(9-15)10-19(32)29-17;/h3-9,12H,10-11H2,1-2H3,(H,29,32)(H2,26,27,28,30);1H2
• InChI 密鑰: XSXCARUUZVMRGX-UHFFFAOYSA-N

说明

應用

PF-431396 hydrate has been used as a dual inhibitor of proline-rich tyrosine kinase 2 (PYK2) / focal adhesion kinase (FAK) inhibitor to study its effects on phosphorylation of Yes-associated protein (YAP) at Ser127 and steady state of transcriptional coactivator with PDZ-binding motif (TAZ) . It has also been used as a PYK2/FAK inhibitor to study its effects on protein kinase A activation in human sperm samples .

生化／生理作用

PF-431396 is a potent inhibitor of PYK2 and FAK kinases (IC₅₀ = 11 and 1.5 nM, respectively). PF-431396 increases bone formation and protects against bone loss in ovariectomized rats.

特點和優勢

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安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301 - H319
• 防範說明: P264 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313 - P405
• 危險分類: Acute Tox. 3 Oral - Eye Irrit. 2
• 儲存類別代碼: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable