PZ0177

OSU6162 hydrochloride

≥98% (HPLC)

• 别名: PNU-96391; PNU-0096391; OSU-6162; (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine hydrochloride; (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride
• 经验公式（希尔记法）: C₁₅H₂₃NO₂S·HCl
• CAS号: 156907-84-5
• 分子量: 317.87
• MDL號碼: MFCD09753276
• 分類程式碼代碼: 51111800
• PubChem物質ID: 329823751
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 光學活性: [α]/D -5 to -7°, c = 1 in methanol
• 顏色: white to tan
• 溶解度: H₂O: ≥16 mg/mL
• 儲存溫度: −20°C
• SMILES 字串: Cl.CCCN1CCC[C@H](C1)c2cccc(c2)S(C)(=O)=O
• InChI: 1S/C15H23NO2S.ClH/c1-3-9-16-10-5-7-14(12-16)13-6-4-8-15(11-13)19(2,17)18;/h4,6,8,11,14H,3,5,7,9-10,12H2,1-2H3;1H/t14-;/m1./s1
• InChI 密鑰: LEMGVHZVBREXAD-PFEQFJNWSA-N

说明

生化／生理作用

OSU6162 (PNU-96391) is a dopamine stabilizer, a drug that can stimulate or inhibit dopaminergic signaling depending on the dopaminergic tone. Dopaminergic stabilizers have been proposed to act as partial dopamine receptor agonists or as antagonists with both dopamine and behavioral stabilizing activity. Although affinity is not high (in vitro binding affinity for dopamine D2 receptor has a Ki of 447 nM), OSU6162 shows a high level of receptor occupancy.

特點和優勢

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

法律資訊

Sold for research purposes under agreement from Pfizer Inc.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H319
• 防範說明: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• 危險分類: Acute Tox. 4 Oral - Eye Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable