跳转至内容
Merck
所有图片(1)

Key Documents

更多文件

PZ0115

Sigma-Aldrich

CP-31398 二盐酸盐 水合物

≥98% (HPLC)

别名:

N′-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride hydrate

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C22H26N4O·2HCl · xH2O
分子量:
435.39 (anhydrous basis)
MDL號碼:
MFCD17215956
分類程式碼代碼:
12352200
PubChem物質ID:
329823707
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

儲存條件

desiccated

顏色

yellow

溶解度

H2O: ≥20 mg/mL

儲存溫度

2-8°C

SMILES 字串

O.Cl.Cl.COc1ccc(cc1)\C=C\c2nc(NCCCN(C)C)c3ccccc3n2

InChI

1S/C22H26N4O.2ClH.H2O/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17;;;/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25);2*1H;1H2/b14-11+;;;

InChI 密鑰

JXIVIAMOMIONKY-UWCBQFGESA-N

基因資訊

human ... TP53(7157)
mouse ... TP53(22059)
rat ... TP53(24842)

應用

CP-31398 dihydrochloride hydrate has been used as a p53 stabilizer:
  • to evaluate its effects on the upregulation of miRNA in human neuroblastoma cells
  • to study its effects on arsenic trioxide (ATO) stabilization of p53 folding
  • to study its effects on regulation of miR-34 in PC12 cells

生化／生理作用

CP-31398 is a styryl quinazoline that functions in preserving the activity of p53 as a tumor suppressor and transcription factor. The DNA-binding activity and apoptosis functionality of the p53 are restored by CP-31398. CP-31398 exhibits therapeutic effects against liver, skin, pancreatic, and colon cancers.
CP-31398 dihyrochloride hydrate is a p53 stabilizer; apoptosis inducer.

特點和優勢

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

William D Johnson et al.
Toxicology, 289(2-3), 141-150 (2011-08-26)
CP-31398 (N'-[2-[2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride) is a styrylquinazoline that stabilizes the DNA binding conformation of p53, thereby maintaining the activity of p53 as a transcription factor and tumor suppressor. In consideration of the potential use of p53 stabilizers for cancer prevention and
Shuo Chen et al.
Cancer cell, 39(2), 225-239 (2020-12-29)
TP53 is the most frequently mutated gene in cancer, yet these mutations remain therapeutically non-actionable. Major challenges in drugging p53 mutations include heterogeneous mechanisms of inactivation and the absence of broadly applicable allosteric sites. Here we report the identification of

商品

Oncogenes and Tumor Suppressors Reprogram Metabolism

We present an article about how proliferating cells require the biosynthesis of structural components for biomass production and for genomic replication.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门