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生物源
Plumbago indica
形狀
powder
顏色
faint orange to dark orange
mp
76-78 °C (lit.)
儲存溫度
−20°C
SMILES 字串
CC1=CC(C2=C(C1=O)C=CC=C2O)=O
InChI
1S/C11H8O3/c1-6-5-9(13)10-7(11(6)14)3-2-4-8(10)12/h2-5,12H,1H3
InChI 密鑰
VCMMXZQDRFWYSE-UHFFFAOYSA-N
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一般說明
白花丹素是一种生物活性萘醌，主要存在于白花丹科植物紫雪花中。它是一种醌类化合物，也来源于白花丹的根。
應用
从紫花丹中提取的白花丹素已用于：
- 作为活性氧试剂(ROS)在小鼠胚胎成纤维细胞中诱导细胞毒性
- 作为一种氧化应激诱导剂，在酿酒酵母中产生超氧阴离子
- 在雪花丹样品白花丹素含量测定的薄层色谱和分光光度分析中作为参考标准品
生化／生理作用
白花丹素具有多种药理活性，包括抗菌、抗癌、抗动脉粥样硬化、抗糖尿病、抗炎、降血脂和神经保护活性。它可以抑制信号转导和转录激活因子3 (STAT3) 信号传导，阻止食管鳞状细胞癌 (ESCC) 的增殖。白花丹素在4-硝基喹啉-N-氧化物 (NQNO) 诱导的淋巴瘤应激中可诱导保护性抗氧化功能。纳米乳剂配方中的白花丹素对前列腺癌具有抗增殖作用。
在癌症和啮齿动物癌症模型中表现出细胞毒性；具有抗真菌、抗病毒和抗菌作用。
訊號詞
Danger
危險分類
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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