P5178

苯巴比妥 钠盐

• 别名: 5-Ethyl-5-phenyl-2,4,6-trioxohexahydropyrimidine sodium salt, 5-Ethyl-5-phenylbarbituric acid sodium salt, Luminal sodium salt, Sodium 5-ethyl-5-phenylbarbiturate
• 经验公式（希尔记法）: C₁₂H₁₁N₂NaO₃
• CAS号: 57-30-7
• 分子量: 254.22
• Beilstein: 3802044
• EC號碼: 200-322-3
• MDL號碼: MFCD00036211
• 分類程式碼代碼: 12352202
• PubChem物質ID: 24898608
• NACRES: NA.77

属性

• 形狀: powder
• 藥物控制: USDEA Schedule IV; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• 溶解度: H₂O: 1 g/mL; ethanol: 100 mg/mL
• 起源: Bayer
• SMILES 字串: [Na+].CCC1(C(=O)NC([O-])=NC1=O)c2ccccc2
• InChI: 1S/C12H12N2O3.Na/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16;/h3-7H,2H2,1H3,(H2,13,14,15,16,17);/q;+1/p-1
• InChI 密鑰: WRLGYAWRGXKSKG-UHFFFAOYSA-M

说明

應用

Phenobarbital sodium salt has been used:

• to anesthetize mice for inducing ischemia-reperfusion injury
• as a positive control for the activation of constitutive androstane receptor (CAR)
• in bioluminescent yeast bioreporters (BLYAS) assay

生化／生理作用

Phenobarbital, a substituted barbituric acid is an antileptic drug and is not easily eliminated from circulation. It hyperpolarizes the synaptic neuronal membranes by favoring the activation of neuronal postsynaptic GABAA receptors by γ aminobutyric acid (GABA). Phenobarbital is also effective in treating neonatal seizures and status epilepticus.

Sedative; hypnotic; anticonvulsant; enhances GABAergic activity.

特點和優勢

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Dopamine and Norepinephrine Metabolism and GABAA Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 象形圖: GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H301,H317,H351
• 防範說明: P202 - P261 - P264 - P280 - P301 + P310 - P302 + P352
• 危險分類: Acute Tox. 3 Oral - Carc. 2 - Skin Sens. 1
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges