推荐产品
product name
吡非尼酮, ≥97% (HPLC)
化驗
≥97% (HPLC)
形狀
powder
溶解度
H2O: >10 mg/mL at 60 °C (warming for 30 minutes)
DMSO: >20 mg/mL
起源
Shionogi
SMILES 字串
O=C(C=CC(C)=C1)N1C2=CC=CC=C2
InChI
1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
InChI 密鑰
ISWRGOKTTBVCFA-UHFFFAOYSA-N
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一般說明
吡非尼酮(5-甲基-1-苯基-2-[1H]-吡啶酮)是合成的吡啶 衍生物。
應用
吡非尼酮用于:
- 作为兔的术后滴眼剂,分析其抗纤维化作用,改进青光眼滤过手术
- 作为抗瘢痕形成剂,检查其是否影响兔植入青光眼引流装置(GDD)后的异物反应
- 在人眼眶成纤维细胞(hOF)原代培养物中测试其抗纤维化潜力
- 作为肿瘤坏死因子(TNFα)抑制剂,研究其在缺氧中的作用
生化/生理作用
吡非尼酮可抑制胶原生成和成纤维细胞增殖。在多种肺纤维化动物模型和临床试验中显示出抗纤维化和抗炎属性。
吡非尼酮用于治疗特发性肺纤维化(IPF)。有助于减少肺功能下降引起的衰弱,延长无进展生存期。吡非尼酮可抑制人Tenon′s 囊成纤维细胞胶原蛋白的增殖和收缩。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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