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Merck
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P152

Sigma-Aldrich

S(–)-Pindolol

solid

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About This Item

经验公式（希尔记法）:
C14H20N2O2
CAS号:
26328-11-0
分子量:
248.32
MDL號碼:
MFCD00153863
分類程式碼代碼:
12352202
PubChem物質ID:
24278026

形狀

solid

品質等級

100

光學活性

[α]23/D −4.38°, c = 1% in methanol(lit.)

顏色

white

溶解度

0.1 M NaOH: 0.2 mg/mL
methanol: 18 mg/mL
0.1 M HCl: 20 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 3.4 mg/mL
H2O: insoluble

起源

Novartis

SMILES 字串

CC(C)NC[C@H](O)COc1cccc2[nH]ccc12

InChI

1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3/t11-/m0/s1

InChI 密鑰

JZQKKSLKJUAGIC-NSHDSACASA-N

基因資訊

human ... ADRB1(153) , HTR1A(3350) , HTR1B(3351)

生化／生理作用

β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator. Active enantiomer of pindolol.

特點和優勢

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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J Ichikawa et al.
Brain research, 842(2), 445-451 (1999-10-20)
Serotonin (5-hydroxytryptamine, 5-HT)(1A) receptor agonism and 5-HT(2A) receptor antagonism are components in the action of some of the recently developed antipsychotic drugs, e.g., clozapine and ziprasidone. However, studies of the role of 5-HT(1A) receptor agonism in the ability of these
D J Watkins et al.
Journal of the autonomic nervous system, 60(1-2), 12-16 (1996-08-27)
The nodose ganglion contains the cell bodies of afferent nerves which convey predominantly sensory information from the viscera to the central nervous system (CNS). Autoradiographic studies show binding sites for beta-adrenoceptor ligands are present on sections of the rat nodose
C A Fornal et al.
The Journal of pharmacology and experimental therapeutics, 291(1), 229-238 (1999-09-22)
Clinical studies have shown that pindolol can enhance the effects of antidepressant drugs, presumably by acting as an antagonist at somatodendritic 5-hydroxytryptamine (5-HT)(1A) autoreceptors, which regulate the firing rate of central serotonergic neurons. The current study characterized the action of
M J Millan et al.
Neuropharmacology, 38(6), 909-912 (1999-08-28)
(-)-Pindolol (2.5-20.0 mg/kg, s.c.) markedly increased extracellular levels of dopamine (DA) and noradrenaline (NA) in single dialysate samples of the frontal cortex (FCX) of freely-moving rats. This action was specific inasmuch as serotonin (5-HT) levels were not significantly modified. In
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the

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