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P101

Sigma-Aldrich

2-Phenylaminoadenosine

>97%, solid

别名:

CV-1808

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About This Item

经验公式（希尔记法）:
C16H18N6O4
CAS号:
53296-10-9
分子量:
358.35
MDL號碼:
MFCD00055119
分類程式碼代碼:
12352200
PubChem物質ID:
24277727
NACRES:
NA.77

品質等級

100

化驗

>97%

形狀

solid

顏色

white

溶解度

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 3.6 mg/mL
H2O: insoluble
absolute ethanol: slightly soluble
ethanol: water (1:1): soluble
methanol: soluble (hot)

儲存溫度

−20°C

SMILES 字串

Nc1nc(Nc2ccccc2)nc3n(cnc13)[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O

InChI

1S/C16H18N6O4/c17-13-10-14(21-16(20-13)19-8-4-2-1-3-5-8)22(7-18-10)15-12(25)11(24)9(6-23)26-15/h1-5,7,9,11-12,15,23-25H,6H2,(H3,17,19,20,21)/t9-,11-,12-,15-/m1/s1

InChI 密鑰

SCNILGOVBBRMBK-SDBHATRESA-N

基因資訊

human ... ADORA2A(135) , ADORA2B(136)
rat ... Adora1(29290) , Adora2a(25369)

生化／生理作用

Selective A2 adenosine receptor agonist; potent coronary vasodilator; weak inhibitor of adenosine uptake by rat cerebral cortical synaptosomes.

重構

Solutions should be freshly prepared.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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D A Taylor et al.
European journal of pharmacology, 85(3-4), 335-338 (1982-12-03)
2-Chloroadenosine (2-CADO) and 2-phenylaminoadenosine (CV 1808) were compared in a CNS purinergic receptor binding assay and the inhibition of neurogenic contractions of the vas deferens. Both 2-CADO and CV 1808 are more potent than adenosine in both preparations. CV 1808
J W Phillis et al.
Pharmacology, biochemistry, and behavior, 24(2), 263-270 (1986-02-01)
Mice were implanted with chronic indwelling cannulae in the lateral cerebral ventricle. A series of adenosine analogs and related compounds were injected into the lateral ventricle (ICVT) and their effects on spontaneous locomotor activity recorded. All analogs produced dose-related decreases
P H Wu et al.
General pharmacology, 15(3), 251-254 (1984-01-01)
Various adenosine derivatives, methylxanthines and other compounds were tested for their abilities to inhibit the rapid uptake of adenosine by rat cerebral cortical synaptosomes. Several pharmacologically potent derivatives of adenosine were weak inhibitors of uptake with IC20 values in excess
Stimulation of Adenosine A
Sarawuth Phosri et al.
Frontiers in pharmacology, 8, 428-428 (2017-07-18)

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