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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
lyophilized powder
物種活性
rat
技術
immunohistochemistry: suitable using rat embryo DRG
western blot: 1:200 using rat dorsal root ganglion (DRG) lysates
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
rat ... P2rx3(81739)
一般說明
The P2X3 (purinergic receptor P2X 3) receptor is expressed in primary afferent neurons. It is a subtype of P2X receptors family of ligand-gated ion channels, activated by extracellular ATP (adenosine triphosphate).
免疫原
peptide (C)VEKQSTDSGAYSIGH corresponding to residues 383-397 of rat P2rx3.
應用
Anti-Purinergic Receptor P2X3 antibody has been used in immunohistochemistry.
生化／生理作用
The P2X3 (purinergic receptor P2X 3) plays a major role in the transmission of pain. Inducing P2X3 generates a desensitizing transient response and initiating P2X2/3 creates a relatively persistent response. P2X3 decreases the sympathetic tone in SH rats.
標靶描述
The P2X3 receptor is highly expressed on nociceptive sensory neurons in dorsal root ganglia (DRG) as a homomer or as a heteromer (P2X3/P2X2). ATP released from damaged cells activates the P2X3 receptor to initiate nociceptive signals. Involvement of ATP in the mechanism of chronic pain contributes to P2X3 receptor as a possible target for the development of pain therapeutics.
外觀
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide.
重構
Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Purinergic receptors in the carotid body as a new drug target for controlling hypertension.
Pijacka W, et al.
Nature Medicine, 22(10), 1151-1151 (2016)
P2X3 receptor involvement in endometriosis pain via ERK signaling pathway.
Ding S, et al.
PLoS ONE, 12(9), e0184647-e0184647 (2017)
LncRNA uc. 48+ is involved in diabetic neuropathic pain mediated by the P2X 3 receptor in the dorsal root ganglia.
Wang S, et al.
Purinergic Signaling, 12(1), 139-148 (2016)
Bradykinin contributes to sympathetic and pressor responses evoked by activation of skeletal muscle afferents P2X in heart failure.
Xing J and Li J
Cellular Physiology and Biochemistry, 39(6), 2101-2109 (2016)
F Florenzano et al.
Neuroscience, 115(2), 425-434 (2002-11-08)
ATP released in the extracellular space by neuronal injury can influence neighboring neurons via activation of purinergic receptors. In vitro data suggest the involvement of ATP and purinergic receptors as trophic agents in different biological events such as neuritogenesis and
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