O3139

Oxamflatin

≥98% (HPLC), solid

• 别名: (2E)-5-[3-(Phenylsulfonylamino)phenyl]-pent-2-en-4-ynohydroxamic acid
• 经验公式（希尔记法）: C₁₇H₁₄N₂O₄S
• CAS号: 151720-43-3
• 分子量: 342.37
• MDL號碼: MFCD00949087
• 分類程式碼代碼: 12352203
• PubChem物質ID: 329818905
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 溶解度: DMSO: soluble 13 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: ONC(=O)\C=C\C#Cc1cccc(NS(=O)(=O)c2ccccc2)c1
• InChI: 1S/C17H14N2O4S/c20-17(18-21)12-5-4-7-14-8-6-9-15(13-14)19-24(22,23)16-10-2-1-3-11-16/h1-3,5-6,8-13,19,21H,(H,18,20)/b12-5+
• InChI 密鑰: QRPSQQUYPMFERG-LFYBBSHMSA-N

说明

應用

Oxamflatin has been used as a histone deacetylase (HDAC) inhibitor:

• to study its effect on specificity protein 1 (Sp1) transcription and transactivation activity and CD1d mRNA expression in various tumor cells
• to study its inhibitory effect on long transcript- survival motor neuron gene 2 (SMN2) silencing mediated by DNA methylation
• to study its effect on somatic embryogenesis in Coffea arabica thorough a miniaturized and automated screening system
• to study its stand-alone effect on cytarabine-sensitive and resistant cells.

生化／生理作用

Histone deacetylase inhibitor; anti-cancer agent.

Oxamflatin is an aromatic sulfonamide derivative with a hydroxamic acid group. It stimulates the expression of the transcription factor, JunD, and fibronectin. In addition, oxamflatin also aids in the morphological reversion of various NIH3T3-derived transformed cell lines. It inhibits the proliferation of various mouse and human tumor cell lines in vitro.

特點和優勢

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)