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产品名称
Osteopontin from mouse, >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
生物源
mouse
品質等級
重組細胞
expressed in NSO cells
無菌
sterile
化驗
>95% (SDS-PAGE)
形狀
lyophilized powder
分子量
30 kDa by SDS-PAGE (reducing)
65 kDa by SDS-PAGE (reducing) (doublet)
包裝
pkg of 50 μg
技術
cell culture | mammalian: suitable
雜質
endotoxin, tested
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
基因資訊
mouse ... Spp1(20750)
相关类别
應用
Osteopontin from mouse has been used:
- to study its role in a mouse model of preterm brain injury
- as a positive control to analyze the relationship between the vascular calcification process and osteopontin (OPN) overexpression in the neointima of atherosclerotic plaques
- to study its interaction on the crystal growth process of hydroxyapatite in agarose hydrogels
生化／生理作用
Osteopontin (OPN) is a secreted, highly acidic, calcium binding, phosphorylated glycoprotein that is chemotactic for macrophages, smooth muscle cells, endothelial cells and glial cells. In activated macrophages, OPN inhibits nitric oxide production and cytotoxicity. Human, mouse, rat, pig and bovine OPN share 40% amino acid sequence identity.
外觀
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.
分析報告
The biological activity is measured by its ability to mediate 293 cell adhesion.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Osteopontin upregulation in atherogenesis is associated with cellular oxidative stress triggered by the activation of scavenger receptors
Jimenez CAE, et al.
Archives of Medical Research, 43(2), 102-111 (2012)
The effect of osteopontin and osteopontin-derived peptides on preterm brain injury
Albertsson AM, et al.
Journal of Neuroinflammation, 11(1), 197-197 (2014)
Effect of osteopontin, chondroitin sulfates (B, C), and human serum albumin on the crystallization behavior of hydroxyapatite in agarose and silica hydrogels
Jimenez CAE, et al.
Crystal Growth & Design, 8(4), 1335-1339 (2008)
Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival
Denhardt DT, et al.
The Journal of Clinical Investigation, 107(9), 1055-1061 (2001)
Yankai Wen et al.
International journal of biological sciences, 11(10), 1236-1247 (2015-09-04)
The initial process in liver regeneration after partial hepatectomy involves the recruitment of immune cells and the release of cytokines. Osteopontin (OPN), a pro-inflammatory protein, plays critical roles in immune cell activation and migration. Although OPN has been implicated in
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