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Merck

O001

Sigma-Aldrich

β-Chlornaltrexamine dihydrochloride

solid

别名:

β-CNA

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About This Item

经验公式(希尔记法):
C24H32Cl2N2O3 · 2HCl
CAS号:
分子量:
540.35
分類程式碼代碼:
12352116
PubChem物質ID:
NACRES:
NA.77

形狀

solid

藥物控制

regulated under CDSA - not available from Sigma-Aldrich Canada

顏色

white

溶解度

H2O: soluble (use aqueous solutions immediately.)
ethanol: soluble (is stable for ca. 1 month in the freezer.)
polar organic solvents: soluble

儲存溫度

−20°C

SMILES 字串

Cl.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)[C@@H](CC[C@@]35O)N(CCCl)CCCl)CC6CC6

InChI

1S/C24H32Cl2N2O3.2ClH/c25-8-11-27(12-9-26)17-5-6-24(30)19-13-16-3-4-18(29)21-20(16)23(24,22(17)31-21)7-10-28(19)14-15-1-2-15;;/h3-4,15,17,19,22,29-30H,1-2,5-14H2;2*1H/t17-,19-,22+,23+,24-;;/m1../s1

InChI 密鑰

JJZDLJGFHABVOM-QNWHWJQFSA-N

生化/生理作用

Irreversible μ, δ and κ opioid receptor antagonist.

特點和優勢

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

注意

Hygroscopic, photosensitive.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Y Pak et al.
Molecular pharmacology, 50(5), 1214-1222 (1996-11-01)
The effects of acute exposure of the opioid peptide [D-Ala2,N-MePhe4, Gly-ol5]enkephalin (DAMGO) on the mu-opioid receptor were examined in Chinese hamster ovary (CHO) K-1 and baby hamster kidney stable transfectants. In the CHO cell line, acute 1-hr treatment with DAMGO
Michael S Virk et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(22), 7341-7348 (2009-06-06)
Buprenorphine is a weak partial agonist at mu-opioid receptors that is used for treatment of pain and addiction. Intracellular and whole-cell recordings were made from locus ceruleus neurons in rat brain slices to characterize the actions of buprenorphine. Acute application
Dimitris E Emmanouil et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 18(3), 194-199 (2007-08-09)
Previous studies have shown that nitrous oxide (N(2)O)-induced antinociception is sensitive to antagonism by blockade of opioid receptors and also by inhibition of nitric oxide (NO) production. The present study was conducted to determine whether these occur within the same
M K James et al.
The Journal of pharmacology and experimental therapeutics, 259(2), 712-718 (1991-11-01)
GI 87084B (3-[4-methoxycarbonyl-4-[(1-oxopropyl) phenylamino]1-piperidine]propanoic acid, methyl ester, hydrochloride) was found to be a potent opioid agonist in the guinea pig ileum (EC50 = 2.4 +/- 0.6 nM), the rat vas deferens (EC50 = 387 +/- 44 nM) and the mouse
D B Joseph et al.
The Journal of pharmacology and experimental therapeutics, 272(3), 970-976 (1995-03-01)
The R1.1 mouse thymoma cell line expresses a single class of kappa opioid receptors that is negatively coupled to adenylyl cyclase through a Bordetella pertussis toxin-sensitive inhibitory guanine nucleotide-binding protein. The aim of the present study was to determine whether

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