N4038
Anti-NAV3 (N-terminal) 兔抗
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-Neuron navigator 3, Anti-Pore membrane and/or filament interacting like protein 1 (POMFIL1), Anti-STEERIN3, Anti-human UNC-53 homolog (unc53H3)
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所有图片(2)
About This Item
分類程式碼代碼:
12352203
NACRES:
NA.41
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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~280 kDa
物種活性
rat (predicted), human, mouse (predicted)
包裝
antibody small pack of 25 μL
加強驗證
recombinant expression
Learn more about Antibody Enhanced Validation
濃度
~1 mg/mL
技術
western blot: 1-2 μg/mL using HEK-293T cells lysate expressing human NAV3 fusion protein
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... NAV3(89795)
mouse ... Nav3(260315)
rat ... Nav3(314814)
一般說明
NAV3 (neuron navigator 3, also known as unc-53H3, steerin3, POMFIL1) belongs to the neuron navigator (NAV) family of proteins. NAV proteins are predominantly expressed in the nervous system. NAV3 expression is detected in brain.
NAV3 is made up of a calponin homology (CH) domain, a cytoskeletal interacting domain (CSID), four coiled-coil (CC) domains, and an AAA-domain.
Neuron navigator 3 (NAV3) is highly expressed in tumors. It possesses actin-binding domains and the gene encoding it is localized on chromosome 12q21.
特異性
Anti-NAV3 (N-terminal) specifically recognizes human NAV3.
生化／生理作用
NAV3 (neuron navigator 3) has been suggested to function as a novel tumor suppressor gene. It is a putative haploin sufficient tumor suppressor gene, which helps in the growth, differentiation and apoptosis of cutaneous T-cell lymphoma (CTCL)cells.
NAV3 gene deletions and translocation affect patients with advanced mycosis fungoides or Sezary syndrome, the most common forms of primary cutaneous T-cell lymphoma (CTCL), suggesting that it may provide a novel diagnostic tool.
Neuron navigator 3 (NAV3) has been shown to control migration and invasion of epithelial cells. Once it is activated by growth factors, NAV3 occupies the ends of microtubules and stimulates their growth.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
儲存和穩定性
For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免責聲明
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Apoorva Uboveja et al.
Oncogenesis, 9(2), 12-12 (2020-02-08)
p73 is a member of the p53 tumor suppressor family, which transactivates p53-responsive genes and mediates DNA damage response. Recent evidences suggest that p73 exerts its tumor suppressor functions by suppressing metastasis, but the exact mechanism remains unknown. Here, we
Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue
Karenko Leena, et al.
Cancer Research, 65(18), 8101-8110 (2005)
Hadas Cohen-Dvashi et al.
EMBO molecular medicine, 7(3), 299-314 (2015-02-14)
Dissemination of primary tumor cells depends on migratory and invasive attributes. Here, we identify Navigator-3 (NAV3), a gene frequently mutated or deleted in human tumors, as a regulator of epithelial migration and invasion. Following induction by growth factors, NAV3 localizes
E Carlsson et al.
British journal of cancer, 106(3), 517-524 (2011-12-17)
The recently described navigator proteins have a multifaceted role in cytoskeletal dynamics. We report here on the relevance of one of them, navigator 3 (NAV3), in colorectal cancer (CRC). We analysed changes in chromosome 12 and NAV3 copy number in
Pilvi Maliniemi et al.
Experimental dermatology, 20(11), 926-931 (2011-10-15)
The neuron navigator 3 (NAV3) gene on chromosome 12q21 encodes a microtubule plus end tracking protein and belongs to the navigator family of cytoskeletal regulators. Loss of heterozygosity on 12q has previously been suggested to be associated with poor prognosis
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