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Merck
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Key Documents

N3536

Sigma-Aldrich

Neuraminidase 5X Reaction Buffer

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About This Item

分類程式碼代碼:
12352204

形狀

liquid

品質等級

儲存溫度

2-8°C

應用

Neuraminidase is a glycoside hydrolase enzyme that is involved in the spread of the influenza virus. It is used to research potential drugs, such as neuraminidase inhibitors, to treat influenza. Neuraminidase mutations are studied for their implications on influenza drug resistance .

生化/生理作用

Neuraminidase cleaves the glycosidic linkages of neuraminic acids. Neuraminidase aids in the dispersment of the flu virus in mucosal secretions of the respiratory tract. It also prevents virions from self-aggregation .

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Larisa V Gubareva
Virus research, 103(1-2), 199-203 (2004-05-28)
A wide use of inhibitors of influenza virus neuraminidase (NAIs) to control influenza in humans demands a better understanding of the mechanisms involved in the resistance emergence. In vitro studies demonstrate that both neuraminidase (NA) and hemagglutinin (HA) influence virus
In vitro passaging of a pandemic H1N1/09 virus selects for viruses with neuraminidase mutations conferring high-level resistance to oseltamivir and peramivir, but not to zanamivir
Jennifer L. McKimm-Breschkin, et al.
The Journal of Antimicrobial Chemotherapy, 10.1093, 150-150 (2012)

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