N1790

Naftifine hydrochloride

• 别名: Naftifine HCL
• 经验公式（希尔记法）: C₂₁H₂₁N · HCl
• CAS号: 65473-14-5
• 分子量: 323.86
• MDL號碼: MFCD00059047
• 分類程式碼代碼: 51102829
• PubChem物質ID: 329818590
• NACRES: NA.76

属性

• 化驗: ≥99%
• 品質等級: 200
• 形狀: powder
• 溶解度: ethanol: soluble 50 mg/mL
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria; fungi; yeast
• 作用方式: cell wall synthesis | interferes; enzyme | inhibits
• 儲存溫度: 2-8°C
• SMILES 字串: Cl.CN(C\C=C\c1ccccc1)Cc2cccc3ccccc23
• InChI: 1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;
• InChI 密鑰: OLUNPKFOFGZHRT-YGCVIUNWSA-N

说明

應用

Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis.

生化／生理作用

Naftifine is an allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria. It has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3-epoxidase. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells.

Allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria and has demonstrated anti-inflammatory properties.

其他說明

Keep container tightly closed in a dry and well-ventilated place.Light sensitive.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: nwg
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable