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N129

Sigma-Aldrich

Naloxone methiodide

≥98% (HPLC), solid

别名:

(5α,17R)-4,5-Epoxy-3,14-dihydroxy-17-methyl-6-oxo-17-(2-propenyl)-morphinanium iodide, N-Methylnaloxonium iodide

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About This Item

经验公式（希尔记法）:
C20H24INO4
CAS号:
93302-47-7
分子量:
469.31
MDL號碼:
MFCD00078592
分類程式碼代碼:
12352200
PubChem物質ID:
24897480
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

solid

藥物控制

regulated under CDSA - not available from Sigma-Aldrich Canada

顏色

white to tan

溶解度

H2O: >10 mg/mL

儲存溫度

2-8°C

SMILES 字串

[I-].[H][C@]12Oc3c(O)ccc4C[C@@H]5[C@](O)(CCC1=O)[C@@]2(CC[N@+]5(C)CC=C)c34

InChI

1S/C20H23NO4.HI/c1-3-9-21(2)10-8-19-16-12-4-5-13(22)17(16)25-18(19)14(23)6-7-20(19,24)15(21)11-12;/h3-5,15,18,24H,1,6-11H2,2H3;1H/t15-,18+,19+,20-,21?;/m1./s1

InChI 密鑰

ICONPJDAXITIPI-UXYWFNEESA-N

應用

Naloxone methiodide has been used as inhibitor of opioid receptor in fish and mice. Naloxone methiodide has been used to block opioid neurotransmission.

生化／生理作用

Naloxone methiodide has low affinity for opioid receptors than naloxone. Administration of naloxone inhibits opioid receptor and opioid-induced respiratory depression.
Quaternary salt of naloxone that, like the parent compound, is a nonselective antagonist at opioid receptors. It does not cross the blood-brain barrier.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
082M4620V
040M46231
040M4623
018K4615
065K4628

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Po-Kuan Chao et al.
PloS one, 7(8), e43680-e43680 (2012-09-01)
Recent studies have shown that opioid treatment can reduce pro-inflammatory cytokine production and counteract various neuropathic pain syndromes. Granulocyte colony-stimulating factor (G-CSF) can promote immune cell differentiation by increasing leukocytes (mainly opioid-containing polymorphonuclear (PMN) cells), suggesting a potential beneficial role
M Makino et al.
British journal of pharmacology, 130(6), 1269-1274 (2000-07-25)
1. We investigated the mechanism by which human interferon-alpha (IFN-alpha) increases the immobility time in a forced swimming test, an animal model of depression. 2. Central administration of IFN-alpha (0.05 - 50 IU per mouse, i.cist.) increased the immobility time
G L Chien et al.
Basic research in cardiology, 94(2), 136-143 (1999-05-18)
The hypothesis that naloxone blockade of ischemic preconditioning (IP)-induced infarct limitation does not require central nervous system participation was evaluated using quaternary naloxone in anesthetized rabbits (Study I) and naloxone hydrochloride in isolated rabbit hearts (Study II). In Study I
Jamie L Laprairie et al.
Frontiers in behavioral neuroscience, 3, 31-31 (2009-10-29)
Studies in both rodents and humans have shown that acute inflammatory pain experienced during the perinatal period produces long-term decreases in pain sensitivity (hypoalgesia) (Grunau et al., 1994a, 2001; Ren et al., 2004; LaPrairie and Murphy, 2007). To date, the
The effect of the mu-opioid receptor antagonist naloxone on extinction of conditioned fear in the developing rat
Kim JH and Richardson R
Learning & Memory, 16(3), 161-1166 (2009)
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