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用途
sufficient for 100 colorimetric or fluorometric tests
檢測方法
colorimetric
fluorometric
相關疾病
cancer
儲存溫度
−20°C
基因資訊
human ... PLD1(5337) , PLD2(5338) , PLD3(23646) , PLD4(122618) , PLD5(200150) , PLD6(201164)
mouse ... PLD1(18805) , PLD2(18806) , PLD3(18807) , PLD4(104759) , PLD5(319455) , PLD6(194908)
rat ... PLD1(25096) , PLD2(25097) , PLD3(361527) , PLD4(362792) , PLD5(289270) , PLD6(287366)
一般說明
磷脂酶 D (PLD) 催化甘油磷脂的磷酸二酯键水解生成磷脂酸和胆碱。它被广泛表达，参与免疫功能和癌症抑制。PLD 表达异常与人类癌症相关，如乳腺癌、肾癌、胃癌和结直肠癌。
應用
适于检测生物样品中的磷脂酶 D 的活性。 本试剂盒可用于研究各种化合物对磷脂酶 D 活性的影响。
采用磷脂酶 D (PLD) 活性检测试剂盒测定了小鼠肝脏和肝脏溶酶体中 PLD 活性。
特點和優勢
兼容高通量的操作系统。
適合性
适用于磷脂酶 D 活性的定量测定及药物对磷脂酶 D 代谢影响的评价。
原則
在本试验中，PLD 将磷脂酰胆碱水解为胆碱，使用胆碱氧化酶进行测定，得到比色 (570 nm)/荧光（λex = 530/λem = 585 nm）乘积，与样品中 PLD 活性成正比。单位定义：在试验条件下 (pH 7.4)，1 个单位的 PLD 每分钟催化 1 mmol 胆碱的形成。
訊號詞
Danger
危險聲明
危險分類
Aquatic Chronic 3 - Resp. Sens. 1
儲存類別代碼
10 - Combustible liquids
閃點（°F）
188.6 °F - closed cup
閃點（°C）
87 °C - closed cup
其他客户在看
Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.
Scott S A, et al.
Nature Chemical Biology, 5(2), 108-108 (2009)
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Journal of plant physiology, 229, 158-163 (2018-08-11)
2,4-dichlorophenoxyacetic acid (2,4-D) is among the most commonly used herbicides applied for weed control during wheat cultivation. However, its application could affect wheat growth. The present study investigates the effect of the ascomycetous fungus Trichoderma harzianum on lipid peroxidation, phospholipids
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Horticulture research, 4, 17042-17042 (2017-11-09)
Raspberry (Rubus spp.) is an economically important crop with a restricted growing season and very limited fruit shelf-life due to its extreme tenderness. In order to prolong its shelf life, an aqueous composition containing hexanal as the key active ingredient
Phospholipase D.
Su W and Michael A F
Handbook of Cell Signaling, 1167-1176 (2009)
Jeong Kuk Park et al.
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Ependymin was first discovered as a predominant protein in brain extracellular fluid in fish and was suggested to be involved in functions mostly related to learning and memory. Orthologous proteins to ependymin called ependymin-related proteins (EPDRs) have been found to
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