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生物源
mouse
品質等級
共軛
unconjugated
抗體表格
tissue culture supernatant
抗體產品種類
primary antibodies
無性繁殖
P3II-26, monoclonal
物種活性
human
濃度
250 μg/mL
技術
immunocytochemistry: 1:20-1:50 using acetone-fixed cytospin preparations
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable (not suitable for human tissues)
immunohistochemistry (frozen sections): 1:20 using acetone-fixed sections
western blot: suitable
同型
IgG2b
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... ABCB11(8647) , ABCB4(5244)
一般說明
多药耐药蛋白3（MDR3）又称ATP结合盒亚家族B成员4。在肝细胞中表达，由1279个氨基酸组成。编码它的基因位于人类染色体7q21.12上，由27个外显子组成。
特異性
与MDR3的内部表位反应。不与人MDR1 P-gp发生交叉反应。
免疫原
MDR3 P-gp（氨基酸629-692）GST融合蛋白。
生化／生理作用
多药耐药性蛋白3（MDR3）充当ATP依赖性输出物，并将磷脂，特别是磷脂酰胆碱（PC）转移到胆汁中。MDR3的功能障碍导致原发性胆汁中胆汁盐的过量，并进一步导致肝脏疾病。
外觀
在含有0.7%牛血清白蛋白和0.1%叠氮化钠的无血清培养基中提供。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Hao-Zhe Sun et al.
World journal of gastroenterology, 21(2), 699-703 (2015-01-17)
Genotyping is conclusive for the diagnosis of progressive familial intrahepatic cholestasis type 3 (PFIC3). Here we report a Chinese patient of PFIC3 with compound mutations in the ABCB4 gene. Liver biopsy was performed on a 17-year-old male patient with intrahepatic
Marianne Kluth et al.
The Journal of biological chemistry, 290(8), 4896-4907 (2014-12-24)
The human multidrug resistance protein 3 (MDR3/ABCB4) belongs to the ubiquitous family of ATP-binding cassette (ABC) transporters and is located in the canalicular membrane of hepatocytes. There it flops the phospholipids of the phosphatidylcholine (PC) family from the inner to
Steffen Kiehl et al.
Scientific reports, 4, 6899-6899 (2014-11-05)
Epigenetic silencing through promoter hypermethylation is an important hallmark for the inactivation of tumor-related genes in carcinogenesis. Here we identified the ATP-binding cassette sub-family B member 4 (ABCB4) as a novel epigenetically silenced target gene. We investigated the epigenetic regulation
Yu Zhao et al.
Journal of lipid research, 56(3), 644-652 (2015-01-21)
ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile. Because SM depletion increases cellular PC content and stimulates PC and cholesterol efflux by ABCA1, a key transporter involved in generation of HDL, we
G J Hooiveld et al.
Gastroenterology, 117(3), 678-687 (1999-08-28)
Biliary cholesterol secretion is coupled to that of phospholipids in a process controlled by mdr2 P-glycoprotein activity and bile salt secretion. Statins, the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, have been shown to affect hepatobiliary lipid secretion in rats. The aim
商品
We presents an article on ABC Transporters and Cancer Drug Resistance
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