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生物源
rabbit
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
rat
技術
microarray: suitable
western blot: 1:500 using rat brain extracts
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... MAGI1(9223)
mouse ... Magi1(14924)
rat ... Cnksr3(308113)
一般說明
The MAGUK (Membrane Associated Guanylate kinase) family of proteins localize to regions of cell-cell contact, such as tight junctions in epithelial cells and synaptic junctions in neurons. In epithelia, membrane associated guanylate kinase, WW And PDZ domain containing 1 (MAGI-1) is localized at tight junctions and is expressed in three isoforms (MAGI-1a, MAGI-1b, and MAGI-1c). MAGI-1 was first identified in mouse as a protein interacting with K-RasB (Ras-like protein rasB).
特異性
Recognizes rat MAGI-1 by immunoblotting (approx. 170, 130, and 120 kDa) and does not cross react with MAGI-2 or MAGI-3.
免疫原
synthetic peptide corresponding to amino acids 282-296 of MAGI-1 with a carboxy terminal added cysteine residue conjugated to maleimide-activated KLH. The sequence is conserved in human and mouse.
應用
Anti-MAGI-1 antibody produced in rabbit has been used in
- immunoblotting
- western blotting
- immunostaining
生化／生理作用
Membrane associated guanylate kinase, WW And PDZ domain containing 1 (MAGI-1) interacts with β-catenin. Neuroepithelial cell-transforming gene 1(nNET1) and actin binding proteins act as binding partners of MAGI-1. Interestingly, MAGI-1c is present in nucleus, suggesting that MAGI-1 may participate in the transmission of regulatory signals from the cell surface to the nucleus.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
E6AP-dependent degradation of DLG4/PSD95 by high-risk human papillomavirus type 18 E6 protein
Handa K, et al.
Journal of Virology, 81(3), 1379-1389 (2007)
Shuqin Jia et al.
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 29(1), 25-35 (2017-04-05)
To explore the association of membrane-associated guanylate kinase inverted 1 (MAGI1) with gastric cancer (GC) and the related molecular mechanisms. The reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry (IHC) were utilized to measure the MAGI1 expression level in GC tissues.
MAGI-1: A Widely Expressed, Alternatively Spliced Tight Junction Protein
Dobrosotskaya IY, et al.
Biochemical and Biophysical Research Communications, 270(3), 903-909 (2000)
Binding of PDZ proteins to HPV E6 proteins does neither correlate with epidemiological risk classification nor with the immortalization of foreskin keratinocytes
Muench P, et al.
Virology, 387(2), 380-387 (2009)
J Zaric et al.
Oncogene, 31(1), 48-59 (2011-06-15)
Cyclooxyganase-2 (COX-2), a rate-limiting enzyme in the prostaglandin synthesis pathway, is overexpressed in many cancers and contributes to cancer progression through tumor cell-autonomous and paracrine effects. Regular use of non-steroidal anti-inflammatory drugs or selective COX-2 inhibitors (COXIBs) reduces the risk
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